ENSMUSG00000020542


Mus musculus

Features
Gene ID: ENSMUSG00000020542
  
Biological name :Myocd
  
Synonyms : Myocardin / Myocd / Q8VIM5
  
Possible biological names infered from orthology : Q8IZQ8
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 65176561
Gene end: 65269989
  
Corresponding Affymetrix probe sets: 10386996 (MoGene1.0st)   1425808_a_at (Mouse Genome 430 2.0 Array)   1425978_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098603
Ensembl peptide - ENSMUSP00000099695
Ensembl peptide - ENSMUSP00000104335
Ensembl peptide - ENSMUSP00000115572
NCBI entrez gene - 214384     See in Manteia.
MGI - MGI:2137495
RefSeq - XM_011248895
RefSeq - NM_145136
RefSeq - NM_146386
RefSeq - XM_006532816
RefSeq - XM_011248893
RefSeq Peptide - NP_660118
RefSeq Peptide - NP_666498
swissprot - Q8VIM5
swissprot - F6TBX6
Ensembl - ENSMUSG00000020542
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkeyp-69b9.3ENSDARG00000088881Danio rerio
 MYOCDENSGALG00000001021Gallus gallus
 MYOCDENSG00000141052Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mkl1 / Q8K4J6 / MKL/myocardin-like protein 1 / Q969V6* / megakaryoblastic leukemia (translocation) 1*ENSMUSG0000004229235
Mkl2 / MKL1/myocardin like 2 / Q9ULH7*ENSMUSG0000000956935


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR004018  RPEL repeat
 IPR028721  Myocardin
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001560 regulation of cell growth by extracellular stimulus IDA
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0003231 cardiac ventricle development IMP
 biological_processGO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IMP
 biological_processGO:0010832 negative regulation of myotube differentiation IMP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0035065 regulation of histone acetylation IDA
 biological_processGO:0035886 vascular smooth muscle cell differentiation IGI
 biological_processGO:0042692 muscle cell differentiation IMP
 biological_processGO:0043388 positive regulation of DNA binding IGI
 biological_processGO:0043954 cellular component maintenance IMP
 biological_processGO:0045661 regulation of myoblast differentiation IMP
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051145 smooth muscle cell differentiation IEA
 biological_processGO:0051152 positive regulation of smooth muscle cell differentiation IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0055012 ventricular cardiac muscle cell differentiation IMP
 biological_processGO:0060065 uterus development IMP
 biological_processGO:0060157 urinary bladder development IMP
 biological_processGO:0097070 ductus arteriosus closure IMP
 biological_processGO:1900222 negative regulation of amyloid-beta clearance IEA
 biological_processGO:1900239 regulation of phenotypic switching IGI
 biological_processGO:1901228 positive regulation of transcription from RNA polymerase II promoter involved in heart development IDA
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IDA
 biological_processGO:1904753 negative regulation of vascular associated smooth muscle cell migration IDA
 biological_processGO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway IDA
 biological_processGO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation IEA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation ISO
 biological_processGO:2001015 negative regulation of skeletal muscle cell differentiation IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0070514 SRF-myogenin-E12 complex IC
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IPI
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0070412 R-SMAD binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myocdtm1.1Msp/Myocdtm1.1Msp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Zdhhc16tm1Goff/Zdhhc16tm1Goff
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Zdhhc16tm1Goff/Zdhhc16tm1Goff
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp
Genetic Background: involves: 129/Sv

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Myocdtm1.1Msp/Myocdtm1.1Msp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
Show

Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Zdhhc16tm1Goff/Zdhhc16tm1Goff
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Zdhhc16tm1Goff/Zdhhc16tm1Goff
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Angptl3tm1Lex/Angptl3tm1Lex,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129/Sv * FVB/N

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0003139 patent ductus arteriosus "failure of the fetal connection between the aorta and pulmonary artery to close within 24 hours after birth" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129/Sv * FVB/N

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp
Genetic Background: involves: 129/Sv

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myocdtm1(cre)Dzw/Myocdtm1(cre)Dzw
Genetic Background: involves: 129 * C57BL/6

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129/Sv * FVB/N

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129/Sv * FVB/N

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plntm1Egk/Plntm1Egk,Zdhhc16tm1Goff/Zdhhc16tm1Goff
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129/Sv * FVB/N

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129/Sv * FVB/N

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129/Sv * FVB/N

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129/Sv * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129/Sv * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Myocdtm1(cre)Dzw/Myocdtm1(cre)Dzw
Genetic Background: involves: 129 * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Trbv14tm2Che/Trbv14tm2Che
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myocdtm1.1Msp/Myocdtm1.1Msp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129/Sv * FVB/N

 MP:0012270 cardiac edema "abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention" [MGI:anna]
Show

Allelic Composition: Myocdtm1(cre)Dzw/Myocdtm1(cre)Dzw
Genetic Background: involves: 129 * C57BL/6

 MP:0020409 abnormal cardiac thrombosis "any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284]
Show

Allelic Composition: Myocdtm1Msp/Myocdtm1Msp,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129/Sv * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr