ENSG00000147601


Homo sapiens

Features
Gene ID: ENSG00000147601
  
Biological name :TERF1
  
Synonyms : P54274 / telomeric repeat binding factor 1 / TERF1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q21.11
Gene start: 73008864
Gene end: 73048122
  
Corresponding Affymetrix probe sets: 203448_s_at (Human Genome U133 Plus 2.0 Array)   203449_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000428838
Ensembl peptide - ENSP00000430121
Ensembl peptide - ENSP00000276602
Ensembl peptide - ENSP00000276603
NCBI entrez gene - 7013     See in Manteia.
OMIM - 600951
RefSeq - XM_017013792
RefSeq - NM_003218
RefSeq - NM_017489
RefSeq - XM_005251291
RefSeq - XM_005251292
RefSeq - XM_011517582
RefSeq Peptide - NP_003209
RefSeq Peptide - NP_059523
swissprot - E7EWM7
swissprot - P54274
swissprot - E5RFJ5
Ensembl - ENSG00000147601
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 terf1ENSDARG00000058710Danio rerio
 TERF1ENSGALG00000037453Gallus gallus
 Terf1ENSMUSG00000025925Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TERF2 / Q15554 / telomeric repeat binding factor 2ENSG0000013260423


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR013867  Telomere repeat-binding factor, dimerisation domain
 IPR017357  Telomeric repeat-binding factor 1/2
 IPR017930  Myb domain
 IPR036507  Telomere repeat-binding factor, dimerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007004 telomere maintenance via telomerase NAS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008156 negative regulation of DNA replication IDA
 biological_processGO:0016233 telomere capping TAS
 biological_processGO:0031627 telomeric loop formation IBA
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase TAS
 biological_processGO:0032214 negative regulation of telomere maintenance via semi-conservative replication NAS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045141 meiotic telomere clustering IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051974 negative regulation of telomerase activity IGI
 biological_processGO:0061820 telomeric D-loop disassembly IGI
 biological_processGO:0090656 t-circle formation TAS
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening TAS
 biological_processGO:1904792 positive regulation of shelterin complex assembly IMP
 biological_processGO:1904850 negative regulation of establishment of protein localization to telomere IMP
 biological_processGO:1904911 negative regulation of establishment of RNA localization to telomere IMP
 biological_processGO:1904914 negative regulation of establishment of protein-containing complex localization to telomere IC
 biological_processGO:1905778 negative regulation of exonuclease activity IDA
 biological_processGO:1905839 negative regulation of telomeric D-loop disassembly IDA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0000783 nuclear telomere cap complex ISS
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0070187 shelterin complex TAS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0003691 double-stranded telomeric DNA binding IDA
 molecular_functionGO:0003720 telomerase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008301 DNA binding, bending IDA
 molecular_functionGO:0042162 telomeric DNA binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0071532 ankyrin repeat binding IPI
 molecular_functionGO:0098505 G-rich strand telomeric DNA binding IDA


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Packaging Of Telomere Ends
DNA Damage/Telomere Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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