ENSMUSG00000025925


Mus musculus

Features
Gene ID: ENSMUSG00000025925
  
Biological name :Terf1
  
Synonyms : P70371 / Telomeric repeat-binding factor 1 / Terf1
  
Possible biological names infered from orthology : P54274
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: A3
Gene start: 15805646
Gene end: 15844052
  
Corresponding Affymetrix probe sets: 10344939 (MoGene1.0st)   1418380_at (Mouse Genome 430 2.0 Array)   1431332_a_at (Mouse Genome 430 2.0 Array)   1443527_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027057
Ensembl peptide - ENSMUSP00000140744
NCBI entrez gene - 21749     See in Manteia.
MGI - MGI:109634
RefSeq - NM_009352
RefSeq - NM_001286628
RefSeq Peptide - NP_001273557
RefSeq Peptide - NP_033378
swissprot - P70371
swissprot - Q3V252
Ensembl - ENSMUSG00000025925
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 terf1ENSDARG00000058710Danio rerio
 TERF1ENSGALG00000037453Gallus gallus
 TERF1ENSG00000147601Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Terf2 / O35144 / Telomeric repeat-binding factor 2 / Q15554*ENSMUSG0000003192124


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR013867  Telomere repeat-binding factor, dimerisation domain
 IPR017357  Telomeric repeat-binding factor 1/2
 IPR017930  Myb domain
 IPR036507  Telomere repeat-binding factor, dimerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0007004 telomere maintenance via telomerase IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint ISO
 biological_processGO:0008156 negative regulation of DNA replication IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization ISO
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0045141 meiotic telomere clustering IMP
 biological_processGO:0045840 positive regulation of mitotic nuclear division ISO
 biological_processGO:0045931 positive regulation of mitotic cell cycle ISO
 biological_processGO:0051260 protein homooligomerization ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051974 negative regulation of telomerase activity IEA
 biological_processGO:0061820 telomeric D-loop disassembly IEA
 biological_processGO:1904792 positive regulation of shelterin complex assembly IEA
 biological_processGO:1904850 negative regulation of establishment of protein localization to telomere IEA
 biological_processGO:1904911 negative regulation of establishment of RNA localization to telomere IEA
 biological_processGO:1905778 negative regulation of exonuclease activity IEA
 biological_processGO:1905839 negative regulation of telomeric D-loop disassembly IEA
 cellular_componentGO:0000781 chromosome, telomeric region ISO
 cellular_componentGO:0000783 nuclear telomere cap complex IDA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0070187 shelterin complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003691 double-stranded telomeric DNA binding IEA
 molecular_functionGO:0003720 telomerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding ISO
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008301 DNA binding, bending IEA
 molecular_functionGO:0042162 telomeric DNA binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0071532 ankyrin repeat binding IEA
 molecular_functionGO:0098505 G-rich strand telomeric DNA binding IEA


Pathways (from Reactome)
Pathway description
Packaging Of Telomere Ends
DNA Damage/Telomere Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000378 absent hair follicles "missing epidermal invaginations from which the hair shaft develops" [J:65039]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000467 abnormal esophagus morphology "malformation of the part of the digestive canal through which food passes from the pharynx to the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000468 abnormal esophageal epithelium morphology "malformation of the epithelial layer of the esophagus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000471 abnormal stomach epithelium morphology "malformation of the epithelial layer of the stomach " [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000579 abnormal nail morphology "structural or developmental anomaly of any of the thin, horny, translucent plates covering the dorsal surface of the distal end of each terminal phalanx of the digits" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000648 absent sebaceous gland "missing the holocrine glands of the dermis that secrete sebum into the hair follicles" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000763 abnormal filiform papillae "malformed keratinized projections on the dorsal surface of the tongue" [J:45400]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000764 abnormal tongue epithelium morphology "malformation of the epithelial layer of the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gusbmps/Gusbmps
Genetic Background: involves: C57BL/6By

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gusbmps/Gusbmps
Genetic Background: involves: C57BL/6By

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gusbmps/Gusbmps
Genetic Background: involves: C57BL/6By

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003155 abnormal telomere length "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0003751 oral leukoplakia "white precancerous lesions of the mucous membranes of the oral cavity" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003941 abnormal skin development "anomaly in the formation of of the membranous protective covering of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005032 abnormal ectoplacental cone 
Show

Allelic Composition: Gusbmps/Gusbmps
Genetic Background: involves: C57BL/6By

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Terf1tm1.1Blas/Terf1tm1.1Blas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Terf1tm2.1Tdl/Terf1tm2.1Tdl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009675 orthokeratosis "thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009704 skin squamous cell carcinoma "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gusbmps/Gusbmps
Genetic Background: involves: C57BL/6By

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Trim71Gt(XD089)Byg/Trim71Gt(XD089)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Terf1tm1Tdl/Terf1tm1Tdl,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Terctm1Rdp/Terctm1Rdp,Terf1tm1Tdl/Terf1tm1Tdl
Genetic Background: involves: 129S2/SvPas

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Gusbmps/Gusbmps
Genetic Background: involves: C57BL/6By

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Gusbmps/Gusbmps
Genetic Background: involves: C57BL/6By

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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