ENSMUSG00000031921


Mus musculus

Features
Gene ID: ENSMUSG00000031921
  
Biological name :Terf2
  
Synonyms : O35144 / Telomeric repeat-binding factor 2 / Terf2
  
Possible biological names infered from orthology : Q15554
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: D3
Gene start: 107069400
Gene end: 107096547
  
Corresponding Affymetrix probe sets: 10581523 (MoGene1.0st)   1421147_at (Mouse Genome 430 2.0 Array)   1455651_at (Mouse Genome 430 2.0 Array)   1459650_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065586
Ensembl peptide - ENSMUSP00000112126
Ensembl peptide - ENSMUSP00000118589
Ensembl peptide - ENSMUSP00000118759
Ensembl peptide - ENSMUSP00000068948
NCBI entrez gene - 21750     See in Manteia.
MGI - MGI:1195972
RefSeq - XM_006530840
RefSeq - NM_001083118
RefSeq - NM_001286200
RefSeq - NM_009353
RefSeq - XM_006530836
RefSeq - XM_006530837
RefSeq - XM_006530838
RefSeq - XM_006530839
RefSeq Peptide - NP_033379
RefSeq Peptide - NP_001076587
RefSeq Peptide - NP_001273129
swissprot - D3YZ08
swissprot - O35144
swissprot - E9QM06
swissprot - F6VIR4
Ensembl - ENSMUSG00000031921
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 terfaENSDARG00000039302Danio rerio
 TERF2ENSGALG00000000657Gallus gallus
 TERF2ENSG00000132604Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Terf1 / P70371 / Telomeric repeat-binding factor 1 / P54274*ENSMUSG0000002592518


Protein motifs (from Interpro)
Interpro ID Name
 IPR001005  SANT/Myb domain
 IPR009057  Homeobox-like domain superfamily
 IPR013867  Telomere repeat-binding factor, dimerisation domain
 IPR017357  Telomeric repeat-binding factor 1/2
 IPR017930  Myb domain
 IPR030657  Telomeric repeat-binding factor 2
 IPR031902  Telomeric repeat-binding factor 2, Rap1-binding domain
 IPR036507  Telomere repeat-binding factor, dimerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance ISS
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006278 RNA-dependent DNA biosynthetic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008089 anterograde axonal transport IMP
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0016233 telomere capping ISO
 biological_processGO:0031627 telomeric loop formation IMP
 biological_processGO:0031848 protection from non-homologous end joining at telomere ISO
 biological_processGO:0032204 regulation of telomere maintenance ISO
 biological_processGO:0032205 negative regulation of telomere maintenance ISO
 biological_processGO:0032206 positive regulation of telomere maintenance IMP
 biological_processGO:0032208 negative regulation of telomere maintenance via recombination IMP
 biological_processGO:0032210 regulation of telomere maintenance via telomerase ISO
 biological_processGO:0032211 negative regulation of telomere maintenance via telomerase ISO
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity ISO
 biological_processGO:0061820 telomeric D-loop disassembly ISO
 biological_processGO:0070198 protein localization to chromosome, telomeric region ISO
 biological_processGO:1903770 negative regulation of beta-galactosidase activity ISO
 biological_processGO:1904354 negative regulation of telomere capping ISO
 biological_processGO:1904357 negative regulation of telomere maintenance via telomere lengthening ISO
 biological_processGO:1904430 negative regulation of t-circle formation ISO
 biological_processGO:1905778 negative regulation of exonuclease activity ISO
 biological_processGO:1905839 negative regulation of telomeric D-loop disassembly ISO
 biological_processGO:2000773 negative regulation of cellular senescence ISO
 cellular_componentGO:0000781 chromosome, telomeric region ISO
 cellular_componentGO:0000783 nuclear telomere cap complex IBA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region ISO
 cellular_componentGO:0001673 male germ cell nucleus IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0030870 Mre11 complex ISO
 cellular_componentGO:0070187 shelterin complex ISO
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003691 double-stranded telomeric DNA binding IMP
 molecular_functionGO:0003720 telomerase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0042162 telomeric DNA binding ISS
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0044877 protein-containing complex binding ISO
 molecular_functionGO:0098505 G-rich strand telomeric DNA binding ISO


Pathways (from Reactome)
Pathway description
Packaging Of Telomere Ends
DNA Damage/Telomere Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nfkbiatm1Stw/Nfkbiatm1Stw
Genetic Background: involves: 129S1/Sv

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfkbiatm1Stw/Nfkbiatm1Stw
Genetic Background: involves: 129S1/Sv

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Tbx1tm2.1Bem/Tbx1tm2.2Bem,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129/Sv * C57BL/6 * SJL * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr