ENSG00000149476


Homo sapiens

Features
Gene ID: ENSG00000149476
  
Biological name :TKFC
  
Synonyms : Q3LXA3 / TKFC / triokinase and FMN cyclase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q12.2
Gene start: 61333210
Gene end: 61353295
  
Corresponding Affymetrix probe sets: 218688_at (Human Genome U133 Plus 2.0 Array)   244627_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000459382
Ensembl peptide - ENSP00000378360
Ensembl peptide - ENSP00000431844
Ensembl peptide - ENSP00000432539
Ensembl peptide - ENSP00000434405
NCBI entrez gene - 26007     See in Manteia.
OMIM - 615844
RefSeq - XM_017017524
RefSeq - XM_011544912
RefSeq - XM_017017517
RefSeq - XM_017017518
RefSeq - XM_017017519
RefSeq - XM_017017520
RefSeq - XM_017017521
RefSeq - XM_017017522
RefSeq - XM_017017523
RefSeq - NM_015533
RefSeq Peptide - NP_056348
RefSeq Peptide - NP_001338905
swissprot - H0YCY6
swissprot - I3L252
swissprot - A0A140VJH7
swissprot - E9PQR1
swissprot - Q3LXA3
swissprot - E9PJG8
Ensembl - ENSG00000149476
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tkfcENSDARG00000062085Danio rerio
 TKFCENSGALG00000037854Gallus gallus
 TkfcENSMUSG00000034371Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004006  DhaK domain
 IPR004007  DhaL domain
 IPR012734  Dihydroxyacetone kinase
 IPR036117  DhaL domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006071 glycerol metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0039534 negative regulation of MDA-5 signaling pathway IDA
 biological_processGO:0044262 cellular carbohydrate metabolic process IDA
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0045088 regulation of innate immune response IDA
 biological_processGO:0046835 carbohydrate phosphorylation IDA
 biological_processGO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate TAS
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004371 glycerone kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0034012 FAD-AMP lyase (cyclizing) activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050354 triokinase activity EXP


Pathways (from Reactome)
Pathway description
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Fructose catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149476 TKFC / Q3LXA3 / triokinase and FMN cyclase  / complex
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / complex






 

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