ENSG00000149485


Homo sapiens

Features
Gene ID: ENSG00000149485
  
Biological name :FADS1
  
Synonyms : FADS1 / fatty acid desaturase 1 / O60427
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q12.2
Gene start: 61799625
Gene end: 61829318
  
Corresponding Affymetrix probe sets: 208962_s_at (Human Genome U133 Plus 2.0 Array)   208963_x_at (Human Genome U133 Plus 2.0 Array)   208964_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443037
Ensembl peptide - ENSP00000446270
Ensembl peptide - ENSP00000445442
Ensembl peptide - ENSP00000445253
Ensembl peptide - ENSP00000443587
Ensembl peptide - ENSP00000322229
Ensembl peptide - ENSP00000391229
Ensembl peptide - ENSP00000405087
Ensembl peptide - ENSP00000407895
Ensembl peptide - ENSP00000416043
Ensembl peptide - ENSP00000429016
Ensembl peptide - ENSP00000438997
Ensembl peptide - ENSP00000439097
Ensembl peptide - ENSP00000439790
Ensembl peptide - ENSP00000440652
Ensembl peptide - ENSP00000441403
Ensembl peptide - ENSP00000441871
Ensembl peptide - ENSP00000442170
NCBI entrez gene - 3992     See in Manteia.
OMIM - 606148
RefSeq - NM_013402
RefSeq - XM_011545022
RefSeq Peptide - NP_037534
swissprot - F5GYH4
swissprot - F5H0Y2
swissprot - F5H1Q7
swissprot - F5H2H3
swissprot - F5H2R9
swissprot - C9JJB3
swissprot - F5H3U5
swissprot - F5H5X5
swissprot - F5H852
swissprot - F5H8G5
swissprot - H0YB97
swissprot - H7C2V0
swissprot - O60427
swissprot - F5H3P6
swissprot - C9J425
swissprot - A0A0A0MR51
swissprot - F5GWE3
Ensembl - ENSG00000149485
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fads2ENSDARG00000019532Danio rerio
 ENSGALG00000007127Gallus gallus
 ENSGALG00000020486Gallus gallus
 ENSGALG00000020485Gallus gallus
 Fads1ENSMUSG00000010663Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FADS2 / O95864 / fatty acid desaturase 2ENSG0000013482454
FADS3 / Q9Y5Q0 / fatty acid desaturase 3ENSG0000022196846


Protein motifs (from Interpro)
Interpro ID Name
 IPR001199  Cytochrome b5-like heme/steroid binding domain
 IPR005804  Fatty acid desaturase domain
 IPR012171  Fatty acid desaturase
 IPR036400  Cytochrome b5-like heme/steroid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006636 unsaturated fatty acid biosynthetic process TAS
 biological_processGO:0007267 cell-cell signaling NAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0008654 phospholipid biosynthetic process TAS
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0009744 response to sucrose IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0019369 arachidonic acid metabolic process IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0035900 response to isolation stress IEA
 biological_processGO:0036109 alpha-linolenic acid metabolic process TAS
 biological_processGO:0043651 linoleic acid metabolic process TAS
 biological_processGO:0045595 regulation of cell differentiation NAS
 biological_processGO:0046456 icosanoid biosynthetic process TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle NAS
 molecular_functionGO:0000248 C-5 sterol desaturase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IDA
 molecular_functionGO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
 molecular_functionGO:0045485 omega-6 fatty acid desaturase activity TAS


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Linoleic acid (LA) metabolism
alpha-linolenic acid (ALA) metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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