ENSMUSG00000010663


Mus musculus

Features
Gene ID: ENSMUSG00000010663
  
Biological name :Fads1
  
Synonyms : Fads1 / Fatty acid desaturase 1 / Q920L1
  
Possible biological names infered from orthology : O60427
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 10182888
Gene end: 10196870
  
Corresponding Affymetrix probe sets: 10461439 (MoGene1.0st)   1423680_at (Mouse Genome 430 2.0 Array)   1440444_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010807
NCBI entrez gene - 76267     See in Manteia.
MGI - MGI:1923517
RefSeq - NM_146094
RefSeq - XM_006527438
RefSeq Peptide - NP_666206
swissprot - Q920L1
Ensembl - ENSMUSG00000010663
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fads2ENSDARG00000019532Danio rerio
 ENSGALG00000007127Gallus gallus
 ENSGALG00000020486Gallus gallus
 ENSGALG00000020485Gallus gallus
 FADS1ENSG00000149485Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fads2 / Q9Z0R9 / Fatty acid desaturase 2 / O95864*ENSMUSG0000002466558
Q0VAX3 / 4833423E24Rik / Fatty acid desaturase 2-like protein FADS2P1 ENSMUSG0000007521752
Fads3 / Q9JJE7 / Fatty acid desaturase 3 / Q9Y5Q0*ENSMUSG0000002466452


Protein motifs (from Interpro)
Interpro ID Name
 IPR001199  Cytochrome b5-like heme/steroid binding domain
 IPR005804  Fatty acid desaturase domain
 IPR012171  Fatty acid desaturase
 IPR036400  Cytochrome b5-like heme/steroid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006636 unsaturated fatty acid biosynthetic process ISO
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0009267 cellular response to starvation ISO
 biological_processGO:0009744 response to sucrose IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019369 arachidonic acid metabolic process IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0035900 response to isolation stress IEA
 biological_processGO:0042759 long-chain fatty acid biosynthetic process ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0016213 linoleoyl-CoA desaturase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity ISO
 molecular_functionGO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA


Pathways (from Reactome)
Pathway description
Linoleic acid (LA) metabolism
alpha-linolenic acid (ALA) metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ryr2tm2.1Maya/Ryr2+
Genetic Background: involves: C57BL/6J

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ryr2tm2.1Maya/Ryr2+
Genetic Background: involves: C57BL/6J

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ryr2tm2.1Maya/Ryr2+
Genetic Background: involves: C57BL/6J

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ryr2tm2.1Maya/Ryr2+
Genetic Background: involves: C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Emx1tm1.1(KOMP)Vlcg/Emx1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Emx1tm1.1(KOMP)Vlcg/Ucd

 MP:0008247 abnormal mononuclear leukocyte morphology "any structural anomaly of a leukocyte with a single non-segmented nucleus in the mature form" [CL:0000842]
Show

Allelic Composition: Ryr2tm2.1Maya/Ryr2+
Genetic Background: involves: C57BL/6J

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ryr2tm2.1Maya/Ryr2+
Genetic Background: involves: C57BL/6J

Allelic Composition: Fads1Gt(IST11525H2)Tigm/Fads1+
Genetic Background: C57BL/6-Fads1Gt(IST11525H2)Tigm

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Ryr2tm2.1Maya/Ryr2+
Genetic Background: involves: C57BL/6J

Allelic Composition: Fads1Gt(IST11525H2)Tigm/Fads1+
Genetic Background: C57BL/6-Fads1Gt(IST11525H2)Tigm

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ryr2tm2.1Maya/Ryr2+
Genetic Background: involves: C57BL/6J

Allelic Composition: Fads1Gt(IST11525H2)Tigm/Fads1+
Genetic Background: C57BL/6-Fads1Gt(IST11525H2)Tigm

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ryr2tm2.1Maya/Ryr2+
Genetic Background: involves: C57BL/6J

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ryr2tm2.1Maya/Ryr2+
Genetic Background: involves: C57BL/6J

Allelic Composition: Fads1Gt(IST11525H2)Tigm/Fads1+
Genetic Background: C57BL/6-Fads1Gt(IST11525H2)Tigm

 MP:0009815 decreased prostaglandin level "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ryr2tm2.1Maya/Ryr2+
Genetic Background: involves: C57BL/6J

Allelic Composition: Fads1Gt(IST11525H2)Tigm/Fads1+
Genetic Background: C57BL/6-Fads1Gt(IST11525H2)Tigm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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