ENSG00000150637


Homo sapiens

Features
Gene ID: ENSG00000150637
  
Biological name :CD226
  
Synonyms : CD226 / CD226 molecule / Q15762
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: -1
Band: q22.2
Gene start: 69831158
Gene end: 69961803
  
Corresponding Affymetrix probe sets: 207315_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464334
Ensembl peptide - ENSP00000463927
Ensembl peptide - ENSP00000464084
Ensembl peptide - ENSP00000280200
Ensembl peptide - ENSP00000461947
Ensembl peptide - ENSP00000462453
Ensembl peptide - ENSP00000463152
Ensembl peptide - ENSP00000463335
NCBI entrez gene - 10666     See in Manteia.
OMIM - 605397
RefSeq - XM_017025527
RefSeq - NM_001303618
RefSeq - NM_001303619
RefSeq - NM_006566
RefSeq - XM_005266642
RefSeq - XM_005266643
RefSeq - XM_006722374
RefSeq - XM_017025524
RefSeq - XM_017025525
RefSeq - XM_017025526
RefSeq Peptide - NP_001290548
RefSeq Peptide - NP_006557
RefSeq Peptide - NP_001290547
swissprot - J3QRQ4
swissprot - J3QL19
swissprot - Q15762
swissprot - J3QKM7
swissprot - J3QQW1
swissprot - J3QR77
Ensembl - ENSG00000150637
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd226ENSDARG00000045391Danio rerio
 CD226ENSGALG00000013748Gallus gallus
 Cd226ENSMUSG00000034028Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IEA
 biological_processGO:0002729 positive regulation of natural killer cell cytokine production IEA
 biological_processGO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
 biological_processGO:0002891 positive regulation of immunoglobulin mediated immune response IDA
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008037 cell recognition TAS
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0033005 positive regulation of mast cell activation IDA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IMP
 biological_processGO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005913 cell-cell adherens junction IBA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft TAS
 molecular_functionGO:0005178 integrin binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0050839 cell adhesion molecule binding IPI


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000073008 PVR / P15151 / poliovirus receptor  / complex / reaction
 ENSG00000130202 Q92692 / NECTIN2 / nectin cell adhesion molecule 2  / reaction / complex






 

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