ENSG00000130202


Homo sapiens

Features
Gene ID: ENSG00000130202
  
Biological name :NECTIN2
  
Synonyms : NECTIN2 / nectin cell adhesion molecule 2 / Q92692
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 44846175
Gene end: 44889228
  
Corresponding Affymetrix probe sets: 203149_at (Human Genome U133 Plus 2.0 Array)   225418_at (Human Genome U133 Plus 2.0 Array)   232078_at (Human Genome U133 Plus 2.0 Array)   232079_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000252485
Ensembl peptide - ENSP00000465587
Ensembl peptide - ENSP00000468305
Ensembl peptide - ENSP00000252483
Ensembl peptide - ENSP00000465511
NCBI entrez gene - 5819     See in Manteia.
OMIM - 600798
RefSeq - XM_011527192
RefSeq - NM_001042724
RefSeq - NM_002856
RefSeq Peptide - NP_001036189
RefSeq Peptide - NP_002847
swissprot - Q92692
swissprot - K7EK87
swissprot - K7EKE8
swissprot - K7ERL3
Ensembl - ENSG00000130202
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pvrl2lENSDARG00000063390Danio rerio
 si:ch73-22o12.1ENSDARG00000062831Danio rerio
 P32507ENSMUSG00000062300Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PVR / P15151 / poliovirus receptorENSG0000007300836
Q15223 / NECTIN1 / nectin cell adhesion molecule 1ENSG0000011040029
Q9NQS3 / NECTIN3 / nectin cell adhesion molecule 3ENSG0000017770725
Q96NY8 / NECTIN4 / nectin cell adhesion molecule 4ENSG0000014321723
CADM2 / Q8N3J6 / cell adhesion molecule 2ENSG0000017516117
CADM3 / Q8N126 / cell adhesion molecule 3ENSG0000016270617
CADM4 / Q8NFZ8 / cell adhesion molecule 4ENSG0000010576715
CADM1 / Q9BY67 / cell adhesion molecule 1ENSG0000018298515
CRTAM / O95727 / cytotoxic and regulatory T cell moleculeENSG000001099439


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR033318  Nectin-2
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001675 acrosome assembly IEA
 biological_processGO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
 biological_processGO:0002891 positive regulation of immunoglobulin mediated immune response IMP
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007286 spermatid development ISS
 biological_processGO:0007289 spermatid nucleus differentiation IEA
 biological_processGO:0008037 cell recognition IBA
 biological_processGO:0009566 fertilization IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019064 fusion of virus membrane with host plasma membrane IDA
 biological_processGO:0030382 sperm mitochondrion organization IEA
 biological_processGO:0032990 cell part morphogenesis IEA
 biological_processGO:0033005 positive regulation of mast cell activation IMP
 biological_processGO:0034332 adherens junction organization TAS
 biological_processGO:0042271 susceptibility to natural killer cell mediated cytotoxicity IMP
 biological_processGO:0044406 adhesion of symbiont to host IDA
 biological_processGO:0044782 cilium organization IEA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP
 biological_processGO:0046596 regulation of viral entry into host cell IDA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0046814 coreceptor-mediated virion attachment to host cell IDA
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IDA
 biological_processGO:0051654 establishment of mitochondrion localization IEA
 biological_processGO:0060370 susceptibility to T cell mediated cytotoxicity IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005913 cell-cell adherens junction IBA
 cellular_componentGO:0005915 zonula adherens IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0043296 apical junction complex IEA
 cellular_componentGO:0044291 cell-cell contact zone IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015026 coreceptor activity TAS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IPI


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adherens junctions interactions
Nectin/Necl trans heterodimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109943 CRTAM / O95727 / cytotoxic and regulatory T cell molecule  / complex / reaction
 ENSG00000130202 Q92692 / NECTIN2 / nectin cell adhesion molecule 2  / complex / reaction
 ENSG00000110400 Q15223 / NECTIN1 / nectin cell adhesion molecule 1  / complex / reaction
 ENSG00000150637 CD226 / Q15762 / CD226 molecule  / complex / reaction
 ENSG00000177707 Q9NQS3 / NECTIN3 / nectin cell adhesion molecule 3  / complex / reaction
 ENSG00000130396 AFDN / P55196 / afadin, adherens junction formation factor  / reaction / complex
 ENSG00000143217 Q96NY8 / NECTIN4 / nectin cell adhesion molecule 4  / reaction / complex






 

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