ENSG00000177707


Homo sapiens

Features
Gene ID: ENSG00000177707
  
Biological name :NECTIN3
  
Synonyms : NECTIN3 / nectin cell adhesion molecule 3 / Q9NQS3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q13.13
Gene start: 111070071
Gene end: 111275563
  
Corresponding Affymetrix probe sets: 213325_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418691
Ensembl peptide - ENSP00000418327
Ensembl peptide - ENSP00000419829
Ensembl peptide - ENSP00000420579
Ensembl peptide - ENSP00000420479
Ensembl peptide - ENSP00000321514
Ensembl peptide - ENSP00000417572
Ensembl peptide - ENSP00000418070
NCBI entrez gene - 25945     See in Manteia.
OMIM - 607147
RefSeq - XM_017006127
RefSeq - NM_001243286
RefSeq - NM_001243288
RefSeq - NM_015480
RefSeq - XM_011512663
RefSeq - XM_017006123
RefSeq - XM_017006124
RefSeq - XM_017006125
RefSeq - XM_017006126
RefSeq Peptide - NP_001230217
RefSeq Peptide - NP_056295
RefSeq Peptide - NP_001230215
swissprot - H7C4L0
swissprot - H7C5G5
swissprot - C9IZE6
swissprot - Q9NQS3
swissprot - C9JMW3
swissprot - C9J795
Ensembl - ENSG00000177707
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR936977.2ENSDARG00000103638Danio rerio
 Q58EG3ENSDARG00000006604Danio rerio
 NECTIN3ENSGALG00000015367Gallus gallus
 Q9JLB9ENSMUSG00000022656Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q15223 / NECTIN1 / nectin cell adhesion molecule 1ENSG0000011040029
Q96NY8 / NECTIN4 / nectin cell adhesion molecule 4ENSG0000014321725
Q92692 / NECTIN2 / nectin cell adhesion molecule 2ENSG0000013020224
PVR / P15151 / poliovirus receptorENSG0000007300820
CADM1 / Q9BY67 / cell adhesion molecule 1ENSG0000018298515
CADM2 / Q8N3J6 / cell adhesion molecule 2ENSG0000017516115
CADM3 / Q8N126 / cell adhesion molecule 3ENSG0000016270615
CADM4 / Q8NFZ8 / cell adhesion molecule 4ENSG0000010576713
CRTAM / O95727 / cytotoxic and regulatory T cell moleculeENSG0000010994310


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR033319  Nectin-3
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002089 lens morphogenesis in camera-type eye IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0008037 cell recognition IBA
 biological_processGO:0009566 fertilization IEA
 biological_processGO:0034332 adherens junction organization TAS
 biological_processGO:0060042 retina morphogenesis in camera-type eye IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1902414 protein localization to cell junction IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043296 apical junction complex IEA
 cellular_componentGO:0044291 cell-cell contact zone IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Adherens junctions interactions
Nectin/Necl trans heterodimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110400 Q15223 / NECTIN1 / nectin cell adhesion molecule 1  / reaction / complex
 ENSG00000130202 Q92692 / NECTIN2 / nectin cell adhesion molecule 2  / complex / reaction
 ENSG00000073008 PVR / P15151 / poliovirus receptor  / complex / reaction
 ENSG00000143217 Q96NY8 / NECTIN4 / nectin cell adhesion molecule 4  / reaction / complex
 ENSG00000177707 Q9NQS3 / NECTIN3 / nectin cell adhesion molecule 3  / complex / reaction
 ENSG00000182985 CADM1 / Q9BY67 / cell adhesion molecule 1  / reaction / complex
 ENSG00000162706 CADM3 / Q8N126 / cell adhesion molecule 3  / reaction / complex
 ENSG00000130396 AFDN / P55196 / afadin, adherens junction formation factor  / complex / reaction






 

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