ENSMUSG00000022656


Mus musculus

Features
Gene ID: ENSMUSG00000022656
  
Biological name :Nectin3
  
Synonyms : Nectin3 / Q9JLB9
  
Possible biological names infered from orthology : nectin cell adhesion molecule 3 / Q9NQS3
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B5
Gene start: 46387706
Gene end: 46498525
  
Corresponding Affymetrix probe sets: 10439766 (MoGene1.0st)   1417319_at (Mouse Genome 430 2.0 Array)   1421132_at (Mouse Genome 430 2.0 Array)   1421133_at (Mouse Genome 430 2.0 Array)   1423331_a_at (Mouse Genome 430 2.0 Array)   1448673_at (Mouse Genome 430 2.0 Array)   1457257_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113146
Ensembl peptide - ENSMUSP00000117479
Ensembl peptide - ENSMUSP00000115927
Ensembl peptide - ENSMUSP00000113301
Ensembl peptide - ENSMUSP00000023334
Ensembl peptide - ENSMUSP00000023335
Ensembl peptide - ENSMUSP00000093757
Ensembl peptide - ENSMUSP00000112567
NCBI entrez gene - 58998     See in Manteia.
MGI - MGI:1930171
RefSeq - XM_006522434
RefSeq - NM_021495
RefSeq - NM_021496
RefSeq - NM_021497
RefSeq Peptide - NP_067472
RefSeq Peptide - NP_067470
RefSeq Peptide - NP_067471
swissprot - D3YWA3
swissprot - F6UII7
swissprot - D3Z657
swissprot - F7A4R2
swissprot - Q9JLB9
swissprot - D3Z6X5
Ensembl - ENSMUSG00000022656
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CR936977.2ENSDARG00000103638Danio rerio
 Q58EG3ENSDARG00000006604Danio rerio
 NECTIN3ENSGALG00000015367Gallus gallus
 Q9NQS3ENSG00000177707Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JKF6 / Nectin1 / Q15223* / nectin cell adhesion molecule 1*ENSMUSG0000003201228
Q8R007 / Nectin4 / Q96NY8* / nectin cell adhesion molecule 4*ENSMUSG0000000641125
P32507 / Nectin2 / Q92692* / nectin cell adhesion molecule 2*ENSMUSG0000006230023
Pvr / poliovirus receptor / P15151*ENSMUSG0000004051119
Cadm1 / Q8R5M8 / Cell adhesion molecule 1 / Q9BY67*ENSMUSG0000003207616
Cadm2 / Q8BLQ9 / Cell adhesion molecule 2 / Q8N3J6*ENSMUSG0000006411515
Cadm3 / Q99N28 / Cell adhesion molecule 3 / Q8N126*ENSMUSG0000000533815
Cadm4 / Q8R464 / Cell adhesion molecule 4 / Q8NFZ8*ENSMUSG0000005479313
Crtam / cytotoxic and regulatory T cell molecule / O95727*ENSMUSG0000003202111


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR033319  Nectin-3
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002089 lens morphogenesis in camera-type eye IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0008037 cell recognition IBA
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 biological_processGO:0098609 cell-cell adhesion IDA
 biological_processGO:1902414 protein localization to cell junction IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043296 apical junction complex IDA
 cellular_componentGO:0044291 cell-cell contact zone IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Adherens junctions interactions
Nectin/Necl trans heterodimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nectin1tm1Ytk/Nectin1+,Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nectin1tm1Ytk/Nectin1tm1Ytk,Nectin3tm1Ytk/Nectin3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0002650 abnormal ameloblast morphology "malformation of the epithelial cells of the inner layer of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Nectin1tm1Ytk/Nectin1+,Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nectin1tm1Ytk/Nectin1tm1Ytk,Nectin3tm1Ytk/Nectin3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002699 abnormal vitreous body "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0003932 abnormal molar crown morphology "defects in the upper part of the molar, which is normally covered with enamel " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nectin1tm1Ytk/Nectin1+,Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nectin1tm1Ytk/Nectin1tm1Ytk,Nectin3tm1Ytk/Nectin3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ

 MP:0005206 abnormal aqueous humor "anomaly in the clear, watery fluid that fills the anterior and posterior chambers of the eye" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0014165 absent ciliary process "absence or loss of any of the pigmented processes that radiate from the ciliary muscle and give attachments to ligaments supporting the lens of the eye; ciliary processes produce aqueous humor" [MGI:Anna]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0014175 abnormal ciliary epithelium morphology "any structural anomaly of the double layer lining the inner surfaces of the ciliary processes and the pars plana (i.e. the posterior portion of the ciliary body, aka orbicularis ciliari); the outer layer is the pigmented epithelium, which is composed of low cuboidal cells and is adjacent to the stroma and continuous with the retinal pigmented epithelium; the inner layer is formed by non-pigmented epithelium, a columnar epithelium, adjacent to the aqueous humor in the posterior chamber and continuous with the retina; these two layers of the epithelium are appositioned in their apical surfaces" [http://cdn.intechopen.com/pdfs-wm/41830.pdf]
Show

Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0030136 abnormal lower incisor morphology "any structural anomaly of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0030138 abnormal lower incisor color "anomaly in the color and shading of the lower incisors, which normally presents in shades of white" [MGI:anna]
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Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0030500 conical molar "a molar tooth whose sides converge or taper together incisally forming a peg-shaped (coniform) crown" [MGI:anna]
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Allelic Composition: Nectin1tm1Ytk/Nectin1+,Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nectin1tm1Ytk/Nectin1tm1Ytk,Nectin3tm1Ytk/Nectin3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030522 abnormal stellate reticulum morphology "any structural anomaly of the network of star-shaped cells found in the core of the dental (enamel) organ between the stratum intermedium and outer enamel epithelium which secrete hydrophilic glycosaminoglycans into the extracellular compartment; the stellate reticulum is most fully developed at the bell stage when intercellular spaces become fluid-filled, presumably related to osmotic effects arising from the high concentration of glycosaminoglycans; the main function of the stellate reticulum is mechanical, protecting the underlying dental tissues against physical disturbance and maintaining tooth shape" [http://dental.pitt.edu/periohistology-glossary, https://pocketdentistry.com/10-early-tooth-development-root-development-including-cementogenesis-and-tooth-eruption/]
Show

Allelic Composition: Nectin1tm1Ytk/Nectin1+,Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nectin1tm1Ytk/Nectin1tm1Ytk,Nectin3tm1Ytk/Nectin3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030523 abnormal stratum intermedium morphology "any structural anomaly of the layer of two or three flattened cells located between the inner enamel epithelium and the newly forming cells of the stellate reticulum; it first appears during the early bell stage of tooth development, has a notably high alkaline phosphatase activity, and forms a part of the dental (enamel) organ; this layer, along with the inner enamel epithelium, is responsible for the tooth enamel formation" [https://en.wikipedia.org/wiki/Stratum_intermedium, https://pocketdentistry.com/10-early-tooth-development-root-development-including-cementogenesis-and-tooth-eruption/]
Show

Allelic Composition: Nectin1tm1Ytk/Nectin1+,Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nectin1tm1Ytk/Nectin1tm1Ytk,Nectin3tm1Ytk/Nectin3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006411 Q8R007 / Nectin4 / Q96NY8* / nectin cell adhesion molecule 4*  / complex / reaction
 ENSMUSG00000022656 Q9JLB9 / Nectin3 / Q9NQS3* / nectin cell adhesion molecule 3*  / reaction / complex
 ENSMUSG00000032012 Q9JKF6 / Nectin1 / Q15223* / nectin cell adhesion molecule 1*  / complex / reaction
 ENSMUSG00000005338 Cadm3 / Q99N28 / Cell adhesion molecule 3 / Q8N126*  / reaction / complex
 ENSMUSG00000062300 P32507 / Nectin2 / Q92692* / nectin cell adhesion molecule 2*  / complex / reaction
 ENSMUSG00000032076 Cadm1 / Q8R5M8 / Cell adhesion molecule 1 / Q9BY67*  / complex / reaction
 ENSMUSG00000040511 Pvr / poliovirus receptor / P15151*  / complex / reaction
 ENSMUSG00000068036 Afdn / Q9QZQ1 / Afadin / P55196* / afadin, adherens junction formation factor*  / complex / reaction






 

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