ENSMUSG00000054793


Mus musculus

Features
Gene ID: ENSMUSG00000054793
  
Biological name :Cadm4
  
Synonyms : Cadm4 / Cell adhesion molecule 4 / Q8R464
  
Possible biological names infered from orthology : Q8NFZ8
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 24482023
Gene end: 24504539
  
Corresponding Affymetrix probe sets: 10550915 (MoGene1.0st)   1426263_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000066880
NCBI entrez gene - 260299     See in Manteia.
MGI - MGI:2449088
RefSeq - NM_153112
RefSeq Peptide - NP_694752
swissprot - Q8R464
Ensembl - ENSMUSG00000054793
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cadm4ENSDARG00000040291Danio rerio
 CADM4ENSG00000105767Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cadm1 / Q8R5M8 / Cell adhesion molecule 1 / Q9BY67*ENSMUSG0000003207638
Cadm2 / Q8BLQ9 / Cell adhesion molecule 2 / Q8N3J6*ENSMUSG0000006411537
Cadm3 / Q99N28 / Cell adhesion molecule 3 / Q8N126*ENSMUSG0000000533835
Q8R007 / Nectin4 / Q96NY8* / nectin cell adhesion molecule 4*ENSMUSG0000000641121
P32507 / Nectin2 / Q92692* / nectin cell adhesion molecule 2*ENSMUSG0000006230021
Q9JKF6 / Nectin1 / Q15223* / nectin cell adhesion molecule 1*ENSMUSG0000003201221
Crtam / cytotoxic and regulatory T cell molecule / O95727*ENSMUSG0000003202118
Q9JLB9 / Nectin3 / Q9NQS3* / nectin cell adhesion molecule 3*ENSMUSG0000002265618
Pvr / poliovirus receptor / P15151*ENSMUSG0000004051116


Protein motifs (from Interpro)
Interpro ID Name
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR028807  Cell adhesion molecule 4
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
 biological_processGO:0008037 cell recognition IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005913 cell-cell adherens junction IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0050839 cell adhesion molecule binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp1a4tm1Blac/Atp1a4tm1Blac
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp1a4tm1Blac/Atp1a4tm1Blac
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp1a4tm1Blac/Atp1a4tm1Blac
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atp1a4tm1Blac/Atp1a4tm1Blac
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1a4tm1Blac/Atp1a4tm1Blac
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1a4tm1Blac/Atp1a4tm1Blac
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010734 abnormal paranode morphology "any structural anomaly of the axon region immediately adjacent to nodes of Ranvier, where a series of cytoplasmic loops from the overlying glial cell form septate-like junctions with the axon; the axoglial junctions act as a diffusion barrier between the node and internode" [PMID:16224497]
Show

Allelic Composition: Atp1a4tm1Blac/Atp1a4tm1Blac
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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