ENSMUSG00000040511


Mus musculus

Features
Gene ID: ENSMUSG00000040511
  
Biological name :Pvr
  
Synonyms : poliovirus receptor / Pvr
  
Possible biological names infered from orthology : P15151
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 19903578
Gene end: 19921160
  
Corresponding Affymetrix probe sets: 10560709 (MoGene1.0st)   1423903_at (Mouse Genome 430 2.0 Array)   1423904_a_at (Mouse Genome 430 2.0 Array)   1423905_at (Mouse Genome 430 2.0 Array)   1429848_at (Mouse Genome 430 2.0 Array)   1445149_at (Mouse Genome 430 2.0 Array)   1450295_s_at (Mouse Genome 430 2.0 Array)   1451160_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039205
NCBI entrez gene - 52118     See in Manteia.
MGI - MGI:107741
RefSeq - NM_027514
RefSeq Peptide - NP_081790
swissprot - Q8K094
Ensembl - ENSMUSG00000040511
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pvrl2lENSDARG00000063390Danio rerio
 si:ch73-22o12.1ENSDARG00000062831Danio rerio
 PVRENSG00000073008Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P32507 / Nectin2 / Q92692* / nectin cell adhesion molecule 2*ENSMUSG0000006230039
Q9JKF6 / Nectin1 / Q15223* / nectin cell adhesion molecule 1*ENSMUSG0000003201230
Q9JLB9 / Nectin3 / Q9NQS3* / nectin cell adhesion molecule 3*ENSMUSG0000002265626
Q8R007 / Nectin4 / Q96NY8* / nectin cell adhesion molecule 4*ENSMUSG0000000641125
Cadm2 / Q8BLQ9 / Cell adhesion molecule 2 / Q8N3J6*ENSMUSG0000006411520
Cadm3 / Q99N28 / Cell adhesion molecule 3 / Q8N126*ENSMUSG0000000533819
Cadm1 / Q8R5M8 / Cell adhesion molecule 1 / Q9BY67*ENSMUSG0000003207617
Cadm4 / Q8R464 / Cell adhesion molecule 4 / Q8NFZ8*ENSMUSG0000005479315
Crtam / cytotoxic and regulatory T cell molecule / O95727*ENSMUSG0000003202113


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IBA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
 biological_processGO:0008037 cell recognition IBA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0042271 susceptibility to natural killer cell mediated cytotoxicity IBA
 biological_processGO:0060370 susceptibility to T cell mediated cytotoxicity IBA
 biological_processGO:0098609 cell-cell adhesion IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005913 cell-cell adherens junction IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0045503 dynein light chain binding IPI
 molecular_functionGO:0050839 cell adhesion molecule binding IBA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Nectin/Necl trans heterodimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sortm1(DTA)Lky,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Pvrtm1Hfuk/Pvr+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034028 Cd226 / Q8K4F0 / CD226 antigen / Q15762* / CD226 molecule*  / reaction / complex
 ENSMUSG00000022657 Cd96 / Q3U0X8 / T-cell surface protein tactile / P40200* / CD96 molecule*  / reaction / complex
 ENSMUSG00000022656 Q9JLB9 / Nectin3 / Q9NQS3* / nectin cell adhesion molecule 3*  / reaction / complex






 

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