ENSMUSG00000032012


Mus musculus

Features
Gene ID: ENSMUSG00000032012
  
Biological name :Nectin1
  
Synonyms : Nectin1 / Q9JKF6
  
Possible biological names infered from orthology : nectin cell adhesion molecule 1 / Q15223
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.1
Gene start: 43743984
Gene end: 43807461
  
Corresponding Affymetrix probe sets: 10584615 (MoGene1.0st)   1438111_at (Mouse Genome 430 2.0 Array)   1438421_at (Mouse Genome 430 2.0 Array)   1450819_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149131
Ensembl peptide - ENSMUSP00000034510
NCBI entrez gene - 58235     See in Manteia.
MGI - MGI:1926483
RefSeq - NM_021424
RefSeq Peptide - NP_067399
swissprot - A0A1L1SQP1
swissprot - Q9JKF6
Ensembl - ENSMUSG00000032012
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nectin1aENSDARG00000069767Danio rerio
 nectin1bENSDARG00000086034Danio rerio
 NECTIN1ENSGALG00000039196Gallus gallus
 Q15223ENSG00000110400Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9JLB9 / Nectin3 / Q9NQS3* / nectin cell adhesion molecule 3*ENSMUSG0000002265630
P32507 / Nectin2 / Q92692* / nectin cell adhesion molecule 2*ENSMUSG0000006230030
Pvr / poliovirus receptor / P15151*ENSMUSG0000004051124
Q8R007 / Nectin4 / Q96NY8* / nectin cell adhesion molecule 4*ENSMUSG0000000641123
Cadm3 / Q99N28 / Cell adhesion molecule 3 / Q8N126*ENSMUSG0000000533817
Cadm1 / Q8R5M8 / Cell adhesion molecule 1 / Q9BY67*ENSMUSG0000003207617
Cadm2 / Q8BLQ9 / Cell adhesion molecule 2 / Q8N3J6*ENSMUSG0000006411517
Cadm4 / Q8R464 / Cell adhesion molecule 4 / Q8NFZ8*ENSMUSG0000005479316
Crtam / cytotoxic and regulatory T cell molecule / O95727*ENSMUSG000000320219


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR033314  Nectin-1
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002089 lens morphogenesis in camera-type eye IMP
 biological_processGO:0002934 desmosome organization IMP
 biological_processGO:0006826 iron ion transport IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0008037 cell recognition IBA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0048593 camera-type eye morphogenesis IMP
 biological_processGO:0051963 regulation of synapse assembly IEA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0070166 enamel mineralization IMP
 biological_processGO:0098609 cell-cell adhesion IMP
 biological_processGO:1902414 protein localization to cell junction IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016342 catenin complex IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0032584 growth cone membrane IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0043296 apical junction complex IDA
 cellular_componentGO:0044291 cell-cell contact zone IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046790 virion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Adherens junctions interactions
Nectin/Necl trans heterodimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trpm7tm1Clph/Trpm7tm1.1Clph,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Nectin1tm1Ytk/Nectin1+,Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nectin1tm1Ytk/Nectin1tm1Ytk,Nectin3tm1Ytk/Nectin3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000126 brittle teeth "fragile and likely to break teeth" [J:61509]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0002649 abnormal enamel rod pattern "anomalous orientation of the structural unit of tooth enamel " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002650 abnormal ameloblast morphology "malformation of the epithelial cells of the inner layer of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nectin1tm1Ytk/Nectin1+,Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nectin1tm1Ytk/Nectin1tm1Ytk,Nectin3tm1Ytk/Nectin3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002699 abnormal vitreous body "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0003932 abnormal molar crown morphology "defects in the upper part of the molar, which is normally covered with enamel " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

Allelic Composition: Nectin1tm1Ytk/Nectin1+,Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nectin1tm1Ytk/Nectin1tm1Ytk,Nectin3tm1Ytk/Nectin3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004830 short incisors "reduced length of the long pointed teeth; most anterior and prominent in the jaw" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0006402 small molars "reduced size of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0010096 abnormal incisor color "anomaly in the color and shading of the incisor, which normally presents in shades of white" [PMID:12407097]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0014165 absent ciliary process "absence or loss of any of the pigmented processes that radiate from the ciliary muscle and give attachments to ligaments supporting the lens of the eye; ciliary processes produce aqueous humor" [MGI:Anna]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0014175 abnormal ciliary epithelium morphology "any structural anomaly of the double layer lining the inner surfaces of the ciliary processes and the pars plana (i.e. the posterior portion of the ciliary body, aka orbicularis ciliari); the outer layer is the pigmented epithelium, which is composed of low cuboidal cells and is adjacent to the stroma and continuous with the retinal pigmented epithelium; the inner layer is formed by non-pigmented epithelium, a columnar epithelium, adjacent to the aqueous humor in the posterior chamber and continuous with the retina; these two layers of the epithelium are appositioned in their apical surfaces" [http://cdn.intechopen.com/pdfs-wm/41830.pdf]
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Allelic Composition: Dlx2tm1Jlr/Dlx2tm1Jlr
Genetic Background: involves: 129X1/SvJ

 MP:0030136 abnormal lower incisor morphology "any structural anomaly of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
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Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0030138 abnormal lower incisor color "anomaly in the color and shading of the lower incisors, which normally presents in shades of white" [MGI:anna]
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Allelic Composition: Rims2tm1Sse/Rims2tm1Sse
Genetic Background: B6.Cg-Rims2tm1Sse

 MP:0030450 abnormal enamel mineralization "anomaly in the process by which calcium salts, mainly carbonated hydroxyapatite, are deposited into the dental enamel" [GO:0070166]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030458 abnormal tooth wear "change in the progression or severity of loss of tooth substance, usually resulting from abrasion, attrition and erosion acting singly or concurrently; tooth wear is a normal, age-dependent physiological process that leads to surface loss of dental hard tissues" [https://www.igi-global.com/dictionary/tooth-wear/45534, https://www.slideshare.net/aneeqa_yaqub/tooth-wear-and-its-types, PMID:22240686]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030459 abnormal tooth attrition "change in the physiologic wearing away of tooth structure as a result of abnormal tooth-to-tooth contact, as in mastication, occurring only on the occlusal, incisal, and proximal surfaces" [PMID:22240686, RDO:0007259]
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Allelic Composition: Nectin1tm1Mjd/Nectin1tm1Mjd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030500 conical molar "a molar tooth whose sides converge or taper together incisally forming a peg-shaped (coniform) crown" [MGI:anna]
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Allelic Composition: Nectin1tm1Ytk/Nectin1+,Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nectin1tm1Ytk/Nectin1tm1Ytk,Nectin3tm1Ytk/Nectin3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030522 abnormal stellate reticulum morphology "any structural anomaly of the network of star-shaped cells found in the core of the dental (enamel) organ between the stratum intermedium and outer enamel epithelium which secrete hydrophilic glycosaminoglycans into the extracellular compartment; the stellate reticulum is most fully developed at the bell stage when intercellular spaces become fluid-filled, presumably related to osmotic effects arising from the high concentration of glycosaminoglycans; the main function of the stellate reticulum is mechanical, protecting the underlying dental tissues against physical disturbance and maintaining tooth shape" [http://dental.pitt.edu/periohistology-glossary, https://pocketdentistry.com/10-early-tooth-development-root-development-including-cementogenesis-and-tooth-eruption/]
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Allelic Composition: Nectin1tm1Ytk/Nectin1+,Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nectin1tm1Ytk/Nectin1tm1Ytk,Nectin3tm1Ytk/Nectin3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0030523 abnormal stratum intermedium morphology "any structural anomaly of the layer of two or three flattened cells located between the inner enamel epithelium and the newly forming cells of the stellate reticulum; it first appears during the early bell stage of tooth development, has a notably high alkaline phosphatase activity, and forms a part of the dental (enamel) organ; this layer, along with the inner enamel epithelium, is responsible for the tooth enamel formation" [https://en.wikipedia.org/wiki/Stratum_intermedium, https://pocketdentistry.com/10-early-tooth-development-root-development-including-cementogenesis-and-tooth-eruption/]
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Allelic Composition: Nectin1tm1Ytk/Nectin1+,Nectin3tm1Ytk/Nectin3tm1Ytk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Nectin1tm1Ytk/Nectin1tm1Ytk,Nectin3tm1Ytk/Nectin3+
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006411 Q8R007 / Nectin4 / Q96NY8* / nectin cell adhesion molecule 4*  / reaction / complex
 ENSMUSG00000022656 Q9JLB9 / Nectin3 / Q9NQS3* / nectin cell adhesion molecule 3*  / complex / reaction
 ENSMUSG00000005338 Cadm3 / Q99N28 / Cell adhesion molecule 3 / Q8N126*  / complex / reaction
 ENSMUSG00000062300 P32507 / Nectin2 / Q92692* / nectin cell adhesion molecule 2*  / reaction / complex
 ENSMUSG00000032012 Q9JKF6 / Nectin1 / Q15223* / nectin cell adhesion molecule 1*  / reaction / complex
 ENSMUSG00000068036 Afdn / Q9QZQ1 / Afadin / P55196* / afadin, adherens junction formation factor*  / reaction / complex






 

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