ENSMUSG00000032021


Mus musculus

Features
Gene ID: ENSMUSG00000032021
  
Biological name :Crtam
  
Synonyms : Crtam / cytotoxic and regulatory T cell molecule
  
Possible biological names infered from orthology : O95727
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.1
Gene start: 40969691
Gene end: 41004628
  
Corresponding Affymetrix probe sets: 10592503 (MoGene1.0st)   1449903_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034519
Ensembl peptide - ENSMUSP00000139826
Ensembl peptide - ENSMUSP00000137837
Ensembl peptide - ENSMUSP00000137749
NCBI entrez gene - 54698     See in Manteia.
MGI - MGI:1859822
RefSeq - NM_019465
RefSeq - NM_001281954
RefSeq Peptide - NP_062338
RefSeq Peptide - NP_001268883
swissprot - A0A087WPL6
swissprot - A0A0R4J297
swissprot - E9QPS7
swissprot - M0QWH9
Ensembl - ENSMUSG00000032021
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX120005.1ENSDARG00000089327Danio rerio
 CRTAMENSGALG00000006527Gallus gallus
 CRTAMENSG00000109943Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cadm2 / Q8BLQ9 / Cell adhesion molecule 2 / Q8N3J6*ENSMUSG0000006411521
Cadm3 / Q99N28 / Cell adhesion molecule 3 / Q8N126*ENSMUSG0000000533820
Cadm4 / Q8R464 / Cell adhesion molecule 4 / Q8NFZ8*ENSMUSG0000005479318
Cadm1 / Q8R5M8 / Cell adhesion molecule 1 / Q9BY67*ENSMUSG0000003207618
Q9JLB9 / Nectin3 / Q9NQS3* / nectin cell adhesion molecule 3*ENSMUSG0000002265615
Q8R007 / Nectin4 / Q96NY8* / nectin cell adhesion molecule 4*ENSMUSG0000000641115
Pvr / poliovirus receptor / P15151*ENSMUSG0000004051113
P32507 / Nectin2 / Q92692* / nectin cell adhesion molecule 2*ENSMUSG0000006230013
Q9JKF6 / Nectin1 / Q15223* / nectin cell adhesion molecule 1*ENSMUSG0000003201212


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002355 detection of tumor cell IEA
 biological_processGO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IEA
 biological_processGO:0008037 cell recognition IEA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0051606 detection of stimulus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp7aMo-brJ/Y
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Rac1tm1Djk/Rac1+,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000062300 P32507 / Nectin2 / Q92692* / nectin cell adhesion molecule 2*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr