ENSG00000109943


Homo sapiens

Features
Gene ID: ENSG00000109943
  
Biological name :CRTAM
  
Synonyms : CRTAM / cytotoxic and regulatory T cell molecule / O95727
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q24.1
Gene start: 122838500
Gene end: 122872639
  
Corresponding Affymetrix probe sets: 206914_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000227348
Ensembl peptide - ENSP00000433728
NCBI entrez gene - 56253     See in Manteia.
OMIM - 612597
RefSeq - XM_011542900
RefSeq - NM_001304782
RefSeq - NM_019604
RefSeq Peptide - NP_062550
RefSeq Peptide - NP_001291711
swissprot - O95727
Ensembl - ENSG00000109943
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX120005.1ENSDARG00000089327Danio rerio
 CRTAMENSGALG00000006527Gallus gallus
 CrtamENSMUSG00000032021Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CADM3 / Q8N126 / cell adhesion molecule 3ENSG0000016270620
CADM1 / Q9BY67 / cell adhesion molecule 1ENSG0000018298520
CADM2 / Q8N3J6 / cell adhesion molecule 2ENSG0000017516119
CADM4 / Q8NFZ8 / cell adhesion molecule 4ENSG0000010576718
Q9NQS3 / NECTIN3 / nectin cell adhesion molecule 3ENSG0000017770714
Q96NY8 / NECTIN4 / nectin cell adhesion molecule 4ENSG0000014321714
Q15223 / NECTIN1 / nectin cell adhesion molecule 1ENSG0000011040013
Q92692 / NECTIN2 / nectin cell adhesion molecule 2ENSG0000013020213
PVR / P15151 / poliovirus receptorENSG0000007300812


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002355 detection of tumor cell IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IDA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
 biological_processGO:0008037 cell recognition IDA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IDA
 biological_processGO:0050715 positive regulation of cytokine secretion IDA
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0051606 detection of stimulus IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005913 cell-cell adherens junction IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0050839 cell adhesion molecule binding IBA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130202 Q92692 / NECTIN2 / nectin cell adhesion molecule 2  / reaction / complex






 

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