ENSG00000073008


Homo sapiens

Features
Gene ID: ENSG00000073008
  
Biological name :PVR
  
Synonyms : P15151 / poliovirus receptor / PVR
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.31
Gene start: 44643798
Gene end: 44663583
  
Corresponding Affymetrix probe sets: 212662_at (Human Genome U133 Plus 2.0 Array)   214443_at (Human Genome U133 Plus 2.0 Array)   214444_s_at (Human Genome U133 Plus 2.0 Array)   216283_s_at (Human Genome U133 Plus 2.0 Array)   239918_at (Human Genome U133 Plus 2.0 Array)   32699_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000402060
Ensembl peptide - ENSP00000187830
Ensembl peptide - ENSP00000383907
Ensembl peptide - ENSP00000385344
Ensembl peptide - ENSP00000466447
Ensembl peptide - ENSP00000340870
NCBI entrez gene - 5817     See in Manteia.
OMIM - 173850
RefSeq - NM_006505
RefSeq - NM_001135768
RefSeq - NM_001135769
RefSeq - NM_001135770
RefSeq Peptide - NP_001129240
RefSeq Peptide - NP_006496
RefSeq Peptide - NP_001129242
RefSeq Peptide - NP_001129241
swissprot - P15151
swissprot - A0A0A0MSA9
swissprot - A0A0C4DG49
swissprot - F8W7D4
swissprot - K7EMC6
Ensembl - ENSG00000073008
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pvrl2lENSDARG00000063390Danio rerio
 si:ch73-22o12.1ENSDARG00000062831Danio rerio
 PvrENSMUSG00000040511Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q92692 / NECTIN2 / nectin cell adhesion molecule 2ENSG0000013020246
Q15223 / NECTIN1 / nectin cell adhesion molecule 1ENSG0000011040030
Q9NQS3 / NECTIN3 / nectin cell adhesion molecule 3ENSG0000017770727
Q96NY8 / NECTIN4 / nectin cell adhesion molecule 4ENSG0000014321726
CADM3 / Q8N126 / cell adhesion molecule 3ENSG0000016270621
CADM2 / Q8N3J6 / cell adhesion molecule 2ENSG0000017516120
CADM1 / Q9BY67 / cell adhesion molecule 1ENSG0000018298518
CADM4 / Q8NFZ8 / cell adhesion molecule 4ENSG0000010576717
CRTAM / O95727 / cytotoxic and regulatory T cell moleculeENSG0000010994312


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
 biological_processGO:0008037 cell recognition IBA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0034332 adherens junction organization TAS
 biological_processGO:0042271 susceptibility to natural killer cell mediated cytotoxicity IMP
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0060370 susceptibility to T cell mediated cytotoxicity IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005913 cell-cell adherens junction IBA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0050839 cell adhesion molecule binding IPI


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Nectin/Necl trans heterodimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000153283 CD96 / P40200 / CD96 molecule  / reaction / complex
 ENSG00000150637 CD226 / Q15762 / CD226 molecule  / reaction / complex
 ENSG00000177707 Q9NQS3 / NECTIN3 / nectin cell adhesion molecule 3  / reaction / complex






 

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