ENSMUSG00000032076


Mus musculus

Features
Gene ID: ENSMUSG00000032076
  
Biological name :Cadm1
  
Synonyms : Cadm1 / Cell adhesion molecule 1 / Q8R5M8
  
Possible biological names infered from orthology : Q9BY67
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A5.3
Gene start: 47530173
Gene end: 47857637
  
Corresponding Affymetrix probe sets: 10585048 (MoGene1.0st)   1417376_a_at (Mouse Genome 430 2.0 Array)   1417377_at (Mouse Genome 430 2.0 Array)   1417378_at (Mouse Genome 430 2.0 Array)   1431611_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124119
Ensembl peptide - ENSMUSP00000110195
Ensembl peptide - ENSMUSP00000124555
Ensembl peptide - ENSMUSP00000149715
Ensembl peptide - ENSMUSP00000034581
Ensembl peptide - ENSMUSP00000083073
Ensembl peptide - ENSMUSP00000110194
NCBI entrez gene - 54725     See in Manteia.
MGI - MGI:1889272
RefSeq - XM_017313489
RefSeq - NM_001025600
RefSeq - NM_001310841
RefSeq - NM_018770
RefSeq - NM_207675
RefSeq - NM_207676
RefSeq - XM_006510497
RefSeq - XM_017313487
RefSeq - XM_017313488
RefSeq Peptide - NP_001020771
RefSeq Peptide - NP_061240
RefSeq Peptide - NP_997558
RefSeq Peptide - NP_997559
RefSeq Peptide - NP_001297770
swissprot - E9PYN1
swissprot - E0CY16
swissprot - A0A1L1SS08
swissprot - Q8R5M8
Ensembl - ENSMUSG00000032076
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cadm1aENSDARG00000031075Danio rerio
 cadm1bENSDARG00000042677Danio rerio
 CADM1ENSGALG00000014582Gallus gallus
 CADM1ENSG00000182985Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cadm2 / Q8BLQ9 / Cell adhesion molecule 2 / Q8N3J6*ENSMUSG0000006411541
Cadm3 / Q99N28 / Cell adhesion molecule 3 / Q8N126*ENSMUSG0000000533832
Cadm4 / Q8R464 / Cell adhesion molecule 4 / Q8NFZ8*ENSMUSG0000005479331
Q9JKF6 / Nectin1 / Q15223* / nectin cell adhesion molecule 1*ENSMUSG0000003201218
Q8R007 / Nectin4 / Q96NY8* / nectin cell adhesion molecule 4*ENSMUSG0000000641118
Q9JLB9 / Nectin3 / Q9NQS3* / nectin cell adhesion molecule 3*ENSMUSG0000002265618
P32507 / Nectin2 / Q92692* / nectin cell adhesion molecule 2*ENSMUSG0000006230016
Pvr / poliovirus receptor / P15151*ENSMUSG0000004051115
Crtam / cytotoxic and regulatory T cell molecule / O95727*ENSMUSG0000003202115


Protein motifs (from Interpro)
Interpro ID Name
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007416 synapse assembly IDA
 biological_processGO:0008037 cell recognition IDA
 biological_processGO:0009826 unidimensional cell growth IMP
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042271 susceptibility to natural killer cell mediated cytotoxicity IDA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IDA
 biological_processGO:0050715 positive regulation of cytokine secretion ISO
 biological_processGO:0051606 detection of stimulus IDA
 biological_processGO:0060348 bone development IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005913 cell-cell adherens junction IBA
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0043196 varicosity IDA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0070852 cell body fiber IDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0050839 cell adhesion molecule binding IBA


Pathways (from Reactome)
Pathway description
Adherens junctions interactions
Nectin/Necl trans heterodimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Sox2tm2Lpev/Sox2tm2Lpev,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cadm1tm1Mrkm/Cadm1tm1Mrkm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: B6Dnk;B6Brd;B6N-Asxl1tm1a(EUCOMM)Wtsi Tyrc-Brd/WtsiH

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Sox2tm2Lpev/Sox2tm2Lpev,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cadm1tm1Mrkm/Cadm1tm1Mrkm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Cadm1tm1Momo/Cadm1tm1Momo
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox2tm2Lpev/Sox2tm2Lpev,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S/SvEv

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox2tm2Lpev/Sox2tm2Lpev,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cadm1tm1Mrkm/Cadm1tm1Mrkm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Cadm1tm1Momo/Cadm1tm1Momo
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Cadm1tm1Mrkm/Cadm1tm1Mrkm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Sox2tm2Lpev/Sox2tm2Lpev,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cadm1tm1Mrkm/Cadm1tm1Mrkm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Cadm1tm1Momo/Cadm1tm1Momo
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0004850 abnormal testis weight "anomaly in the average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadm1tm1Momo/Cadm1tm1Momo
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadm1tm1Mrkm/Cadm1tm1Mrkm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadm1tm1Momo/Cadm1tm1Momo
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Asxl1tm1a(EUCOMM)Wtsi/Asxl1+
Genetic Background: B6Dnk;B6Brd;B6N-Asxl1tm1a(EUCOMM)Wtsi Tyrc-Brd/WtsiH

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox2tm2Lpev/Sox2tm2Lpev,Tg(Pax6-cre,GFP)2Pgr/?
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cadm1tm1Mrkm/Cadm1tm1Mrkm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Cadm1tm1Momo/Cadm1tm1Momo
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadm1tm1Momo/Cadm1tm1Momo
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0008279 arrest of spermiogenesis "block in the process by which a spermatid transforms into a functional spermatozoon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadm1tm1Momo/Cadm1tm1Momo
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0008754 abnormal T cell receptor V(D)J recombination "any anomaly in the process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus" [GO:0033153, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecomtm1.1Miku/Mecom+
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0009239 short sperm flagellum "decreased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadm1tm1Mrkm/Cadm1tm1Mrkm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009839 multiflagellated sperm "presence of more than one sperm flagellum, displaying either one common origin from the sperm head or multiple origins from the same sperm head" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadm1tm1Mrkm/Cadm1tm1Mrkm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011819 increased pancreatic beta cell proliferation "increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
Show

Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022656 Q9JLB9 / Nectin3 / Q9NQS3* / nectin cell adhesion molecule 3*  / reaction / complex
 ENSMUSG00000064115 Cadm2 / Q8BLQ9 / Cell adhesion molecule 2 / Q8N3J6*  / reaction / complex
 ENSMUSG00000005338 Cadm3 / Q99N28 / Cell adhesion molecule 3 / Q8N126*  / complex / reaction
 ENSMUSG00000032076 Cadm1 / Q8R5M8 / Cell adhesion molecule 1 / Q9BY67*  / complex / reaction






 

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