ENSMUSG00000062300


Mus musculus

Features
Gene ID: ENSMUSG00000062300
  
Biological name :Nectin2
  
Synonyms : Nectin2 / P32507
  
Possible biological names infered from orthology : nectin cell adhesion molecule 2 / Q92692
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 19716644
Gene end: 19750483
  
Corresponding Affymetrix probe sets: 10560644 (MoGene1.0st)   1417703_at (Mouse Genome 430 2.0 Array)   1424456_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074898
Ensembl peptide - ENSMUSP00000104089
NCBI entrez gene - 19294     See in Manteia.
MGI - MGI:97822
RefSeq - NM_001159724
RefSeq - NM_008990
RefSeq Peptide - NP_001153196
RefSeq Peptide - NP_033016
swissprot - P32507
Ensembl - ENSMUSG00000062300
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pvrl2lENSDARG00000063390Danio rerio
 si:ch73-22o12.1ENSDARG00000062831Danio rerio
 Q92692ENSG00000130202Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pvr / poliovirus receptor / P15151*ENSMUSG0000004051130
Q9JKF6 / Nectin1 / Q15223* / nectin cell adhesion molecule 1*ENSMUSG0000003201229
Q9JLB9 / Nectin3 / Q9NQS3* / nectin cell adhesion molecule 3*ENSMUSG0000002265624
Q8R007 / Nectin4 / Q96NY8* / nectin cell adhesion molecule 4*ENSMUSG0000000641122
Cadm2 / Q8BLQ9 / Cell adhesion molecule 2 / Q8N3J6*ENSMUSG0000006411517
Cadm3 / Q99N28 / Cell adhesion molecule 3 / Q8N126*ENSMUSG0000000533817
Cadm1 / Q8R5M8 / Cell adhesion molecule 1 / Q9BY67*ENSMUSG0000003207615
Cadm4 / Q8R464 / Cell adhesion molecule 4 / Q8NFZ8*ENSMUSG0000005479315
Crtam / cytotoxic and regulatory T cell molecule / O95727*ENSMUSG0000003202110


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR033318  Nectin-2
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001675 acrosome assembly IMP
 biological_processGO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target ISO
 biological_processGO:0002891 positive regulation of immunoglobulin mediated immune response ISO
 biological_processGO:0007010 cytoskeleton organization IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IDA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0007289 spermatid nucleus differentiation IMP
 biological_processGO:0008037 cell recognition IBA
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0019064 fusion of virus membrane with host plasma membrane ISO
 biological_processGO:0030382 sperm mitochondrion organization IMP
 biological_processGO:0032990 cell part morphogenesis IMP
 biological_processGO:0033005 positive regulation of mast cell activation ISO
 biological_processGO:0042271 susceptibility to natural killer cell mediated cytotoxicity IBA
 biological_processGO:0044406 adhesion of symbiont to host ISO
 biological_processGO:0044782 cilium organization IMP
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity ISO
 biological_processGO:0046596 regulation of viral entry into host cell ISO
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0046814 coreceptor-mediated virion attachment to host cell ISO
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway ISO
 biological_processGO:0051654 establishment of mitochondrion localization IMP
 biological_processGO:0060370 susceptibility to T cell mediated cytotoxicity ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0005911 cell-cell junction ISO
 cellular_componentGO:0005915 zonula adherens IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0043296 apical junction complex IDA
 cellular_componentGO:0044291 cell-cell contact zone IDA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IPI


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adherens junctions interactions
Nectin/Necl trans heterodimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0003666 impaired sperm capacitation "anomaly in the change undergone by spermatozoa in the female genital tract that enables them to penetrate and fertilize an egg" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96669]
Show

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009280 reduced activated sperm motility "loss or reduction of the activated type of sperm mobility, resulting in immotile sperm that are generally unable to reach the uterotubal junction; decreases in activated sperm motility may result in reduced male fertility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006411 Q8R007 / Nectin4 / Q96NY8* / nectin cell adhesion molecule 4*  / complex / reaction
 ENSMUSG00000022656 Q9JLB9 / Nectin3 / Q9NQS3* / nectin cell adhesion molecule 3*  / complex / reaction
 ENSMUSG00000032021 Crtam / cytotoxic and regulatory T cell molecule / O95727*  / reaction / complex
 ENSMUSG00000034028 Cd226 / Q8K4F0 / CD226 antigen / Q15762* / CD226 molecule*  / complex / reaction
 ENSMUSG00000032012 Q9JKF6 / Nectin1 / Q15223* / nectin cell adhesion molecule 1*  / reaction / complex
 ENSMUSG00000062300 P32507 / Nectin2 / Q92692* / nectin cell adhesion molecule 2*  / reaction / complex
 ENSMUSG00000068036 Afdn / Q9QZQ1 / Afadin / P55196* / afadin, adherens junction formation factor*  / complex / reaction






 

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