ENSG00000151790


Homo sapiens

Features
Gene ID: ENSG00000151790
  
Biological name :TDO2
  
Synonyms : P48775 / TDO2 / tryptophan 2,3-dioxygenase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q32.1
Gene start: 155854738
Gene end: 155920406
  
Corresponding Affymetrix probe sets: 205943_at (Human Genome U133 Plus 2.0 Array)   231702_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423394
Ensembl peptide - ENSP00000444788
Ensembl peptide - ENSP00000424384
NCBI entrez gene - 6999     See in Manteia.
OMIM - 191070
RefSeq - NM_005651
RefSeq Peptide - NP_005642
swissprot - D6RB68
swissprot - D6RA50
swissprot - P48775
Ensembl - ENSG00000151790
  
Related genetic diseases (OMIM): 600627 - [?Hypertryptophanemia], 600627
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tdo2aENSDARG00000071429Danio rerio
 tdo2bENSDARG00000023176Danio rerio
 TDO2ENSGALG00000035207Gallus gallus
 Tdo2ENSMUSG00000028011Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004981  Tryptophan 2,3-dioxygenase
 IPR037217  Tryptophan/Indoleamine 2,3-dioxygenase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006568 tryptophan metabolic process IEA
 biological_processGO:0006569 tryptophan catabolic process IEA
 biological_processGO:0019441 tryptophan catabolic process to kynurenine IDA
 biological_processGO:0019442 tryptophan catabolic process to acetyl-CoA IEA
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004833 tryptophan 2,3-dioxygenase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0019825 oxygen binding IEA
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Tryptophan catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000151790 TDO2 / P48775 / tryptophan 2,3-dioxygenase  / complex






 

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