ENSMUSG00000028011


Mus musculus

Features
Gene ID: ENSMUSG00000028011
  
Biological name :Tdo2
  
Synonyms : P48776 / Tdo2 / tryptophan 2,3-dioxygenase
  
Possible biological names infered from orthology : P48775
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E3
Gene start: 81957090
Gene end: 81976202
  
Corresponding Affymetrix probe sets: 10498921 (MoGene1.0st)   1419093_at (Mouse Genome 430 2.0 Array)   1449337_at (Mouse Genome 430 2.0 Array)   1455770_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141237
Ensembl peptide - ENSMUSP00000029645
NCBI entrez gene - 56720     See in Manteia.
MGI - MGI:1928486
RefSeq - NM_019911
RefSeq Peptide - NP_064295
swissprot - C5NSA7
swissprot - P48776
swissprot - Q8VCW3
Ensembl - ENSMUSG00000028011
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tdo2aENSDARG00000071429Danio rerio
 tdo2bENSDARG00000023176Danio rerio
 TDO2ENSGALG00000035207Gallus gallus
 TDO2ENSG00000151790Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004981  Tryptophan 2,3-dioxygenase
 IPR037217  Tryptophan/Indoleamine 2,3-dioxygenase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006568 tryptophan metabolic process IEA
 biological_processGO:0006569 tryptophan catabolic process IEA
 biological_processGO:0019441 tryptophan catabolic process to kynurenine IEA
 biological_processGO:0019442 tryptophan catabolic process to acetyl-CoA IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0004833 tryptophan 2,3-dioxygenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0019825 oxygen binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Tryptophan catabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Foxn1nu/Foxn1+
Genetic Background: C.Cg-Foxn1nu

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Foxn1nu/Foxn1+
Genetic Background: C.Cg-Foxn1nu

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: T6J/T+
Genetic Background: involves: A/J * C57BL/6J

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: T6J/T+
Genetic Background: involves: A/J * C57BL/6J

 MP:0003136 yellow coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is increased compared to wild-type agouti" [llw2:Linda L. Washburn, Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1nu/Foxn1+
Genetic Background: C.Cg-Foxn1nu

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: T6J/T+
Genetic Background: involves: A/J * C57BL/6J

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: T6J/T+
Genetic Background: involves: A/J * C57BL/6J

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: T6J/T+
Genetic Background: involves: A/J * C57BL/6J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: T6J/T+
Genetic Background: involves: A/J * C57BL/6J

 MP:0010069 increased serotonin concentration "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: T6J/T+
Genetic Background: involves: A/J * C57BL/6J

 MP:0013908 small lateral ventricles "decreased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650]
Show

Allelic Composition: T6J/T+
Genetic Background: involves: A/J * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028011 Tdo2 / P48776 / tryptophan 2,3-dioxygenase / P48775*  / complex






 

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