ENSG00000152377


Homo sapiens

Features
Gene ID: ENSG00000152377
  
Biological name :SPOCK1
  
Synonyms : Q08629 / SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1 / SPOCK1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.2
Gene start: 136975298
Gene end: 137598379
  
Corresponding Affymetrix probe sets: 202363_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000282223
Ensembl peptide - ENSP00000424517
Ensembl peptide - ENSP00000421677
Ensembl peptide - ENSP00000378401
NCBI entrez gene - 6695     See in Manteia.
OMIM - 602264
RefSeq - NM_004598
RefSeq Peptide - NP_004589
swissprot - D6RB21
swissprot - D6RAM7
swissprot - A0A0A0MQX7
swissprot - Q08629
Ensembl - ENSG00000152377
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 spock1ENSDARG00000074644Danio rerio
 SPOCK1ENSGALG00000006258Gallus gallus
 Spock1ENSMUSG00000056222Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9BQ16 / SPOCK3 / SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3ENSG0000019610451
Q92563 / SPOCK2 / SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2ENSG0000010774243


Protein motifs (from Interpro)
Interpro ID Name
 IPR000716  Thyroglobulin type-1
 IPR002350  Kazal domain
 IPR011992  EF-hand domain pair
 IPR019577  SPARC/Testican, calcium-binding domain
 IPR036058  Kazal domain superfamily
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth NAS
 biological_processGO:0001764 neuron migration ISS
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007399 nervous system development NAS
 biological_processGO:0010812 negative regulation of cell-substrate adhesion IDA
 biological_processGO:0010951 negative regulation of endopeptidase activity IDA
 biological_processGO:0010977 negative regulation of neuron projection development IDA
 biological_processGO:0021953 central nervous system neuron differentiation ISS
 biological_processGO:0022008 neurogenesis ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0014069 postsynaptic density NAS
 cellular_componentGO:0016528 sarcoplasm ISS
 cellular_componentGO:0031594 neuromuscular junction ISS
 cellular_componentGO:0033268 node of Ranvier ISS
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity NAS
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008191 metalloendopeptidase inhibitor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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