ENSG00000153827


Homo sapiens

Features
Gene ID: ENSG00000153827
  
Biological name :TRIP12
  
Synonyms : Q14669 / thyroid hormone receptor interactor 12 / TRIP12
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q36.3
Gene start: 229763838
Gene end: 229923239
  
Corresponding Affymetrix probe sets: 201546_at (Human Genome U133 Plus 2.0 Array)   226993_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400967
Ensembl peptide - ENSP00000389827
Ensembl peptide - ENSP00000408330
Ensembl peptide - ENSP00000414385
Ensembl peptide - ENSP00000409460
Ensembl peptide - ENSP00000283943
Ensembl peptide - ENSP00000342442
Ensembl peptide - ENSP00000373696
Ensembl peptide - ENSP00000373697
Ensembl peptide - ENSP00000386388
NCBI entrez gene - 9320     See in Manteia.
OMIM - 604506
RefSeq - XM_017005293
RefSeq - XM_017005278
RefSeq - XM_017005279
RefSeq - XM_017005280
RefSeq - XM_017005281
RefSeq - XM_017005282
RefSeq - XM_017005283
RefSeq - XM_017005284
RefSeq - XM_017005285
RefSeq - XM_017005286
RefSeq - XM_017005287
RefSeq - XM_017005288
RefSeq - XM_017005289
RefSeq - XM_017005290
RefSeq - XM_017005291
RefSeq - XM_017005292
RefSeq - NM_001284214
RefSeq - NM_001284215
RefSeq - NM_001284216
RefSeq - NM_001348315
RefSeq - NM_001348331
RefSeq - NM_001348333
RefSeq - NM_004238
RefSeq - XM_005246954
RefSeq - XM_005246955
RefSeq - XM_005246956
RefSeq - XM_005246957
RefSeq - XM_005246958
RefSeq - XM_005246960
RefSeq - XM_005246961
RefSeq - XM_005246962
RefSeq - XM_006712852
RefSeq - XM_011512180
RefSeq - XM_011512181
RefSeq - XM_011512183
RefSeq - XM_017005272
RefSeq - XM_017005273
RefSeq - XM_017005274
RefSeq - XM_017005275
RefSeq - XM_017005276
RefSeq - XM_017005277
RefSeq Peptide - NP_001271144
RefSeq Peptide - NP_001271145
RefSeq Peptide - NP_001335244
RefSeq Peptide - NP_001335260
RefSeq Peptide - NP_001335262
RefSeq Peptide - NP_004229
RefSeq Peptide - NP_001271143
swissprot - C9JSX9
swissprot - Q14669
swissprot - C9JLJ5
swissprot - F8W9P3
swissprot - G5E9G6
swissprot - H7C1L9
swissprot - H7C2Y1
swissprot - C9JLD7
Ensembl - ENSG00000153827
  
Related genetic diseases (OMIM): 617752 - Mental retardation, autosomal dominant 49, 617752
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 F1RCR6ENSDARG00000061397Danio rerio
 TRIP12ENSGALG00000002929Gallus gallus
 G5E870ENSMUSG00000026219Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HECTD1 / Q9ULT8 / HECT domain E3 ubiquitin protein ligase 1ENSG0000009214817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000569  HECT domain
 IPR004170  WWE domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR018123  WWE domain, subgroup
 IPR035983  HECT, E3 ligase catalytic domain
 IPR037197  WWE domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0045995 regulation of embryonic development IEA
 biological_processGO:1901315 negative regulation of histone H2A K63-linked ubiquitination IMP
 biological_processGO:2000780 negative regulation of double-strand break repair IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046966 thyroid hormone receptor binding IDA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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