ENSMUSG00000026219


Mus musculus

Features
Gene ID: ENSMUSG00000026219
  
Biological name :Trip12
  
Synonyms : G5E870 / thyroid hormone receptor interactor 12 / Trip12
  
Possible biological names infered from orthology : Q14669
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C5
Gene start: 84721189
Gene end: 84840516
  
Corresponding Affymetrix probe sets: 10356194 (MoGene1.0st)   1423898_a_at (Mouse Genome 430 2.0 Array)   1423899_at (Mouse Genome 430 2.0 Array)   1423900_at (Mouse Genome 430 2.0 Array)   1423901_at (Mouse Genome 430 2.0 Array)   1443125_at (Mouse Genome 430 2.0 Array)   1447073_at (Mouse Genome 430 2.0 Array)   1451158_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139986
Ensembl peptide - ENSMUSP00000139682
Ensembl peptide - ENSMUSP00000140224
Ensembl peptide - ENSMUSP00000141035
Ensembl peptide - ENSMUSP00000140917
Ensembl peptide - ENSMUSP00000140879
Ensembl peptide - ENSMUSP00000140817
Ensembl peptide - ENSMUSP00000140789
Ensembl peptide - ENSMUSP00000140675
Ensembl peptide - ENSMUSP00000140267
Ensembl peptide - ENSMUSP00000027421
Ensembl peptide - ENSMUSP00000139563
NCBI entrez gene - 14897     See in Manteia.
MGI - MGI:1309481
RefSeq - XM_017316673
RefSeq - XM_011238665
RefSeq - XM_011238666
RefSeq - XM_011238667
RefSeq - XM_011238668
RefSeq - XM_011238669
RefSeq - XM_011238670
RefSeq - XM_011238671
RefSeq - XM_011238672
RefSeq - XM_011238673
RefSeq - XM_011238674
RefSeq - XM_017316494
RefSeq - XM_017316627
RefSeq - NM_133975
RefSeq - XM_006496409
RefSeq - XM_006496414
RefSeq - XM_006496416
RefSeq - XM_006496422
RefSeq - XM_006496427
RefSeq - XM_006496429
RefSeq - XM_011238654
RefSeq - XM_011238655
RefSeq - XM_011238656
RefSeq - XM_011238657
RefSeq - XM_011238658
RefSeq - XM_011238659
RefSeq - XM_011238660
RefSeq - XM_011238661
RefSeq - XM_011238662
RefSeq - XM_011238663
RefSeq - XM_011238664
RefSeq Peptide - NP_598736
swissprot - A0A087WSG4
swissprot - A0A087WS65
swissprot - A0A087WS33
swissprot - A0A087WRV6
swissprot - A0A087WRK9
swissprot - A0A087WQ02
swissprot - G5E870
swissprot - A0A087WP92
swissprot - A0A087WNZ7
swissprot - A0A0B4J1N9
swissprot - Q3TP48
Ensembl - ENSMUSG00000026219
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 F1RCR6ENSDARG00000061397Danio rerio
 TRIP12ENSGALG00000002929Gallus gallus
 Q14669ENSG00000153827Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hectd1 / Q69ZR2 / E3 ubiquitin-protein ligase HECTD1 / Q9ULT8* / HECT domain E3 ubiquitin protein ligase 1*ENSMUSG0000003524717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000569  HECT domain
 IPR004170  WWE domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR018123  WWE domain, subgroup
 IPR035983  HECT, E3 ligase catalytic domain
 IPR037197  WWE domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0045995 regulation of embryonic development IMP
 biological_processGO:1901315 negative regulation of histone H2A K63-linked ubiquitination IEA
 biological_processGO:2000780 negative regulation of double-strand break repair IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046966 thyroid hormone receptor binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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