ENSG00000154328


Homo sapiens

Features
Gene ID: ENSG00000154328
  
Biological name :NEIL2
  
Synonyms : NEIL2 / nei like DNA glycosylase 2 / Q969S2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p23.1
Gene start: 11769639
Gene end: 11787346
  
Corresponding Affymetrix probe sets: 226585_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397538
Ensembl peptide - ENSP00000394023
Ensembl peptide - ENSP00000435657
Ensembl peptide - ENSP00000437004
Ensembl peptide - ENSP00000284503
Ensembl peptide - ENSP00000384070
NCBI entrez gene - 252969     See in Manteia.
OMIM - 608933
RefSeq - XM_017013301
RefSeq - NM_001135746
RefSeq - NM_001135747
RefSeq - NM_001135748
RefSeq - NM_001349439
RefSeq - NM_001349440
RefSeq - NM_001349442
RefSeq - NM_145043
RefSeq - XM_005272382
RefSeq - XM_005272383
RefSeq Peptide - NP_001129218
RefSeq Peptide - NP_001129220
RefSeq Peptide - NP_001336371
RefSeq Peptide - NP_659480
RefSeq Peptide - NP_001129219
RefSeq Peptide - NP_001336368
RefSeq Peptide - NP_001336369
RefSeq Peptide - NP_001336370
swissprot - E9PPL4
swissprot - A0A024R361
swissprot - Q969S2
Ensembl - ENSG00000154328
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 neil3ENSDARG00000020079Danio rerio
 NEIL2ENSGALG00000016664Gallus gallus
 Neil2ENSMUSG00000035121Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NEIL3 / Q8TAT5 / nei like DNA glycosylase 3ENSG0000010967418


Protein motifs (from Interpro)
Interpro ID Name
 IPR000214  Zinc finger, DNA glycosylase/AP lyase-type
 IPR010979  Ribosomal protein S13-like, H2TH
 IPR012319  Formamidopyrimidine-DNA glycosylase, catalytic domain
 IPR015886  DNA glycosylase/AP lyase, H2TH DNA-binding
 IPR035937  MutM-like, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IEA
 biological_processGO:0006289 nucleotide-excision repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0045008 depyrimidination TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005876 spindle microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0019104 DNA N-glycosylase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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