ENSG00000156261


Homo sapiens

Features
Gene ID: ENSG00000156261
  
Biological name :CCT8
  
Synonyms : CCT8 / chaperonin containing TCP1 subunit 8 / P50990
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q21.3
Gene start: 29055805
Gene end: 29073797
  
Corresponding Affymetrix probe sets: 200873_s_at (Human Genome U133 Plus 2.0 Array)   210436_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407748
Ensembl peptide - ENSP00000442730
Ensembl peptide - ENSP00000486921
Ensembl peptide - ENSP00000286788
Ensembl peptide - ENSP00000416832
NCBI entrez gene - 10694     See in Manteia.
OMIM - 617786
RefSeq - NM_001282907
RefSeq - NM_001282908
RefSeq - NM_001282909
RefSeq - NM_006585
RefSeq Peptide - NP_001269837
RefSeq Peptide - NP_001269836
RefSeq Peptide - NP_006576
RefSeq Peptide - NP_001269838
swissprot - P50990
swissprot - H7C4C8
swissprot - H7C2U0
Ensembl - ENSG00000156261
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cct8ENSDARG00000008243Danio rerio
 CCT8ENSGALG00000015821Gallus gallus
 Cct8ENSMUSG00000025613Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCT8L2 / Q96SF2 / chaperonin containing TCP1 subunit 8 like 2ENSG0000019844531


Protein motifs (from Interpro)
Interpro ID Name
 IPR002194  Chaperonin TCP-1, conserved site
 IPR002423  Chaperonin Cpn60/TCP-1 family
 IPR012721  T-complex protein 1, theta subunit
 IPR017998  Chaperone tailless complex polypeptide 1 (TCP-1)
 IPR027409  GroEL-like apical domain superfamily
 IPR027413  GroEL-like equatorial domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0006458 "de novo" protein folding IBA
 biological_processGO:0007339 binding of sperm to zona pellucida IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0046931 pore complex assembly IEA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0061077 chaperone-mediated protein folding IBA
 biological_processGO:1901998 toxin transport IEA
 biological_processGO:1904851 positive regulation of establishment of protein localization to telomere IMP
 biological_processGO:1904871 positive regulation of protein localization to Cajal body IMP
 biological_processGO:1904874 positive regulation of telomerase RNA localization to Cajal body IMP
 cellular_componentGO:0002199 zona pellucida receptor complex IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005832 chaperonin-containing T-complex TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0042623 ATPase activity, coupled TAS
 molecular_functionGO:0044183 protein binding involved in protein folding IBA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051082 unfolded protein binding IBA


Pathways (from Reactome)
Pathway description
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Folding of actin by CCT/TriC
Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Neutrophil degranulation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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