ENSG00000159131


Homo sapiens

Features
Gene ID: ENSG00000159131
  
Biological name :GART
  
Synonyms : GART / P22102 / phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q22.11
Gene start: 33503931
Gene end: 33543491
  
Corresponding Affymetrix probe sets: 210005_at (Human Genome U133 Plus 2.0 Array)   212378_at (Human Genome U133 Plus 2.0 Array)   212379_at (Human Genome U133 Plus 2.0 Array)   216990_at (Human Genome U133 Plus 2.0 Array)   217445_s_at (Human Genome U133 Plus 2.0 Array)   230097_at (Human Genome U133 Plus 2.0 Array)   230766_at (Human Genome U133 Plus 2.0 Array)   236969_at (Human Genome U133 Plus 2.0 Array)   244822_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000390003
Ensembl peptide - ENSP00000398631
Ensembl peptide - ENSP00000413803
Ensembl peptide - ENSP00000413040
Ensembl peptide - ENSP00000409771
Ensembl peptide - ENSP00000407783
Ensembl peptide - ENSP00000354388
Ensembl peptide - ENSP00000371236
Ensembl peptide - ENSP00000371253
Ensembl peptide - ENSP00000371261
NCBI entrez gene - 2618     See in Manteia.
OMIM - 138440
RefSeq - XM_011529526
RefSeq - NM_000819
RefSeq - NM_001136005
RefSeq - NM_001136006
RefSeq - NM_175085
RefSeq - XM_005260941
RefSeq - XM_006723989
RefSeq - XM_006723990
RefSeq Peptide - NP_001129477
RefSeq Peptide - NP_000810
RefSeq Peptide - NP_001129478
RefSeq Peptide - NP_780294
swissprot - C9JBJ1
swissprot - F8WD69
swissprot - H7C366
swissprot - C9JKQ7
swissprot - C9JZG2
swissprot - C9JTV6
swissprot - P22102
Ensembl - ENSG00000159131
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gartENSDARG00000101089Danio rerio
 GARTENSGALG00000037076Gallus gallus
 GartENSMUSG00000022962Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000115  Phosphoribosylglycinamide synthetase
 IPR001555  Phosphoribosylglycinamide formyltransferase, active site
 IPR002376  Formyl transferase, N-terminal
 IPR004607  Phosphoribosylglycinamide formyltransferase
 IPR004733  Phosphoribosylformylglycinamidine cyclo-ligase
 IPR010918  PurM-like, C-terminal domain
 IPR011054  Rudiment single hybrid motif
 IPR011761  ATP-grasp fold
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily
 IPR016188  PurM-like, N-terminal domain
 IPR020559  Phosphoribosylglycinamide synthetase, conserved site
 IPR020560  Phosphoribosylglycinamide synthetase, C-domain
 IPR020561  Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
 IPR020562  Phosphoribosylglycinamide synthetase, N-terminal
 IPR036477  Formyl transferase, N-terminal domain superfamily
 IPR036676  PurM-like, C-terminal domain superfamily
 IPR036921  PurM-like, N-terminal domain superfamily
 IPR037123  Phosphoribosylglycinamide synthetase, C-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003360 brainstem development IEA
 biological_processGO:0006164 purine nucleotide biosynthetic process IEA
 biological_processGO:0006189 "de novo" IMP biosynthetic process IEA
 biological_processGO:0006544 glycine metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0009113 purine nucleobase biosynthetic process IEA
 biological_processGO:0009156 ribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0009168 purine ribonucleoside monophosphate biosynthetic process TAS
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010035 response to inorganic substance IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0046654 tetrahydrofolate biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004637 phosphoribosylamine-glycine ligase activity IEA
 molecular_functionGO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity IEA
 molecular_functionGO:0004644 phosphoribosylglycinamide formyltransferase activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016742 hydroxymethyl-, formyl- and related transferase activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Purine ribonucleoside monophosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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