ENSMUSG00000022962


Mus musculus

Features
Gene ID: ENSMUSG00000022962
  
Biological name :Gart
  
Synonyms : Gart / Mus musculus phosphoribosylglycinamide formyltransferase (Gart), transcript variant 2, mRNA. / Q64737
  
Possible biological names infered from orthology : P22102 / phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C3.3
Gene start: 91621186
Gene end: 91646952
  
Corresponding Affymetrix probe sets: 10440929 (MoGene1.0st)   1416283_at (Mouse Genome 430 2.0 Array)   1424435_a_at (Mouse Genome 430 2.0 Array)   1424436_at (Mouse Genome 430 2.0 Array)   1441911_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023684
Ensembl peptide - ENSMUSP00000114034
Ensembl peptide - ENSMUSP00000119272
NCBI entrez gene - 14450     See in Manteia.
MGI - MGI:95654
RefSeq - XM_006522912
RefSeq - NM_001357351
RefSeq - NM_010256
RefSeq - XM_006522910
RefSeq - XM_006522911
RefSeq Peptide - NP_001344280
RefSeq Peptide - NP_034386
swissprot - Q3TH49
swissprot - Q64737
swissprot - D6RCG1
Ensembl - ENSMUSG00000022962
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gartENSDARG00000101089Danio rerio
 GARTENSGALG00000037076Gallus gallus
 GARTENSG00000159131Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000115  Phosphoribosylglycinamide synthetase
 IPR001555  Phosphoribosylglycinamide formyltransferase, active site
 IPR002376  Formyl transferase, N-terminal
 IPR004607  Phosphoribosylglycinamide formyltransferase
 IPR004733  Phosphoribosylformylglycinamidine cyclo-ligase
 IPR010918  PurM-like, C-terminal domain
 IPR011054  Rudiment single hybrid motif
 IPR011761  ATP-grasp fold
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily
 IPR016188  PurM-like, N-terminal domain
 IPR020559  Phosphoribosylglycinamide synthetase, conserved site
 IPR020560  Phosphoribosylglycinamide synthetase, C-domain
 IPR020561  Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
 IPR020562  Phosphoribosylglycinamide synthetase, N-terminal
 IPR036477  Formyl transferase, N-terminal domain superfamily
 IPR036676  PurM-like, C-terminal domain superfamily
 IPR036921  PurM-like, N-terminal domain superfamily
 IPR037123  Phosphoribosylglycinamide synthetase, C-domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003360 brainstem development IEA
 biological_processGO:0006164 purine nucleotide biosynthetic process IEA
 biological_processGO:0006189 "de novo" IMP biosynthetic process IEA
 biological_processGO:0006544 glycine metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0009113 purine nucleobase biosynthetic process IEA
 biological_processGO:0009156 ribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010035 response to inorganic substance IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0046654 tetrahydrofolate biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004637 phosphoribosylamine-glycine ligase activity IEA
 molecular_functionGO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity IEA
 molecular_functionGO:0004644 phosphoribosylglycinamide formyltransferase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016742 hydroxymethyl-, formyl- and related transferase activity IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Purine ribonucleoside monophosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Fustm1.1(KOMP)Vlcg/Fustm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fustm1.1(KOMP)Vlcg/Ucd

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fustm1.1(KOMP)Vlcg/Fustm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fustm1.1(KOMP)Vlcg/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Fustm1.1(KOMP)Vlcg/Fustm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fustm1.1(KOMP)Vlcg/Ucd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Fustm1.1(KOMP)Vlcg/Fustm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fustm1.1(KOMP)Vlcg/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Fustm1.1(KOMP)Vlcg/Fustm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fustm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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