ENSG00000159339


Homo sapiens

Features
Gene ID: ENSG00000159339
  
Biological name :PADI4
  
Synonyms : PADI4 / peptidyl arginine deiminase 4 / Q9UM07
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.13
Gene start: 17308195
Gene end: 17364004
  
Corresponding Affymetrix probe sets: 211412_at (Human Genome U133 Plus 2.0 Array)   211413_s_at (Human Genome U133 Plus 2.0 Array)   220001_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364602
Ensembl peptide - ENSP00000364597
NCBI entrez gene - 23569     See in Manteia.
OMIM - 605347
RefSeq - XM_011541157
RefSeq - NM_012387
RefSeq - XM_011541153
RefSeq - XM_011541154
RefSeq - XM_011541156
RefSeq - XM_011541150
RefSeq - XM_011541151
RefSeq - XM_011541152
RefSeq Peptide - NP_036519
swissprot - Q9UM07
swissprot - B1AQ67
Ensembl - ENSG00000159339
  
Related genetic diseases (OMIM): 180300 - {Rheumatoid arthritis, susceptibility to}, 180300
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Padi4ENSMUSG00000025330Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PADI1 / Q9ULC6 / peptidyl arginine deiminase 1ENSG0000014262357
PADI3 / Q9ULW8 / peptidyl arginine deiminase 3ENSG0000014261956
PADI2 / Q9Y2J8 / peptidyl arginine deiminase 2ENSG0000011711550
PADI6 / Q6TGC4 / peptidyl arginine deiminase 6ENSG0000027674746


Protein motifs (from Interpro)
Interpro ID Name
 IPR004303  Protein-arginine deiminase
 IPR008972  Cupredoxin
 IPR013530  Protein-arginine deiminase, C-terminal
 IPR013732  Protein-arginine deiminase (PAD) N-terminal
 IPR013733  Protein-arginine deiminase (PAD), central domain
 IPR036556  Protein-arginine deiminase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006325 chromatin organization TAS
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0018101 protein citrullination IMP
 biological_processGO:0019546 arginine deiminase pathway IMP
 biological_processGO:0019827 stem cell population maintenance IEA
 biological_processGO:0036413 histone H3-R26 citrullination IDA
 biological_processGO:0036414 histone citrullination IDA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032991 protein-containing complex IMP
 molecular_functionGO:0004668 protein-arginine deiminase activity IMP
 molecular_functionGO:0005509 calcium ion binding IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016990 arginine deiminase activity IDA
 molecular_functionGO:0034618 arginine binding IMP
 molecular_functionGO:0042803 protein homodimerization activity IMP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Chromatin modifying enzymes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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