ENSG00000117115


Homo sapiens

Features
Gene ID: ENSG00000117115
  
Biological name :PADI2
  
Synonyms : PADI2 / peptidyl arginine deiminase 2 / Q9Y2J8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.13
Gene start: 17066761
Gene end: 17119435
  
Corresponding Affymetrix probe sets: 1554384_at (Human Genome U133 Plus 2.0 Array)   1554385_a_at (Human Genome U133 Plus 2.0 Array)   209791_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364630
Ensembl peptide - ENSP00000364635
NCBI entrez gene - 11240     See in Manteia.
OMIM - 607935
RefSeq - NM_007365
RefSeq Peptide - NP_031391
swissprot - A0A024RA98
swissprot - Q9Y2J8
Ensembl - ENSG00000117115
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 padi2ENSDARG00000044167Danio rerio
 PADI2ENSGALG00000029212Gallus gallus
 Padi2ENSMUSG00000028927Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PADI3 / Q9ULW8 / peptidyl arginine deiminase 3ENSG0000014261952
PADI1 / Q9ULC6 / peptidyl arginine deiminase 1ENSG0000014262352
PADI4 / Q9UM07 / peptidyl arginine deiminase 4ENSG0000015933950
PADI6 / Q6TGC4 / peptidyl arginine deiminase 6ENSG0000027674745


Protein motifs (from Interpro)
Interpro ID Name
 IPR004303  Protein-arginine deiminase
 IPR008972  Cupredoxin
 IPR013530  Protein-arginine deiminase, C-terminal
 IPR013732  Protein-arginine deiminase (PAD) N-terminal
 IPR013733  Protein-arginine deiminase (PAD), central domain
 IPR036556  Protein-arginine deiminase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization TAS
 biological_processGO:0010848 regulation of chromatin disassembly IDA
 biological_processGO:0018101 protein citrullination IDA
 biological_processGO:0021762 substantia nigra development HEP
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IMP
 biological_processGO:0036413 histone H3-R26 citrullination IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0048096 chromatin-mediated maintenance of transcription IMP
 biological_processGO:0070100 negative regulation of chemokine-mediated signaling pathway IDA
 biological_processGO:1901624 negative regulation of lymphocyte chemotaxis IDA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0035327 transcriptionally active chromatin IDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004668 protein-arginine deiminase activity IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030331 estrogen receptor binding IPI


Pathways (from Reactome)
Pathway description
Chromatin modifying enzymes
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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