ENSMUSG00000028927


Mus musculus

Features
Gene ID: ENSMUSG00000028927
  
Biological name :Padi2
  
Synonyms : Padi2 / Protein-arginine deiminase type-2 / Q08642
  
Possible biological names infered from orthology : peptidyl arginine deiminase 2 / Q9Y2J8
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 140906344
Gene end: 140952586
  
Corresponding Affymetrix probe sets: 10509838 (MoGene1.0st)   1418252_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030765
NCBI entrez gene - 18600     See in Manteia.
MGI - MGI:1338892
RefSeq - NM_008812
RefSeq - XM_006538632
RefSeq Peptide - NP_032838
swissprot - Q08642
Ensembl - ENSMUSG00000028927
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 padi2ENSDARG00000044167Danio rerio
 PADI2ENSGALG00000029212Gallus gallus
 PADI2ENSG00000117115Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Padi1 / Q9Z185 / Protein-arginine deiminase type-1 / Q9ULC6* / peptidyl arginine deiminase 1*ENSMUSG0000002532951
Padi4 / Q9Z183 / Protein-arginine deiminase type-4 / Q9UM07* / peptidyl arginine deiminase 4*ENSMUSG0000002533050
Padi3 / Q9Z184 / Protein-arginine deiminase type-3 / Q9ULW8* / peptidyl arginine deiminase 3*ENSMUSG0000002532850
Padi6 / Q8K3V4 / Protein-arginine deiminase type-6 / Q6TGC4* / peptidyl arginine deiminase 6*ENSMUSG0000004093539


Protein motifs (from Interpro)
Interpro ID Name
 IPR004303  Protein-arginine deiminase
 IPR008972  Cupredoxin
 IPR013530  Protein-arginine deiminase, C-terminal
 IPR013732  Protein-arginine deiminase (PAD) N-terminal
 IPR013733  Protein-arginine deiminase (PAD), central domain
 IPR036556  Protein-arginine deiminase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010848 regulation of chromatin disassembly IEA
 biological_processGO:0018101 protein citrullination ISO
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0036413 histone H3-R26 citrullination IEA
 biological_processGO:0036414 histone citrullination IBA
 biological_processGO:0048096 chromatin-mediated maintenance of transcription IEA
 biological_processGO:0070100 negative regulation of chemokine-mediated signaling pathway IEA
 biological_processGO:1901624 negative regulation of lymphocyte chemotaxis IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0035327 transcriptionally active chromatin IEA
 molecular_functionGO:0004668 protein-arginine deiminase activity ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA


Pathways (from Reactome)
Pathway description
Chromatin modifying enzymes
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: KitW-sh/KitW-sh
Genetic Background: involves: 101/H * C3H/HeH * CBA

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hexbtm1Rlp/Hexbtm1Rlp,Tg(SYN1-tTA2S,tetO-Hexb)#Tjsa/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Izumo1rtm2a(KOMP)Wtsi/Izumo1rtm2a(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm2a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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