ENSG00000160223


Homo sapiens

Features
Gene ID: ENSG00000160223
  
Biological name :ICOSLG
  
Synonyms : ICOSLG / inducible T cell costimulator ligand / O75144
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q22.3
Gene start: 44217014
Gene end: 44240966
  
Corresponding Affymetrix probe sets: 211197_s_at (Human Genome U133 Plus 2.0 Array)   211198_s_at (Human Genome U133 Plus 2.0 Array)   211199_s_at (Human Genome U133 Plus 2.0 Array)   213450_s_at (Human Genome U133 Plus 2.0 Array)   228976_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000339477
Ensembl peptide - ENSP00000383230
Ensembl peptide - ENSP00000384432
Ensembl peptide - ENSP00000494882
Ensembl peptide - ENSP00000383228
NCBI entrez gene - 23308     See in Manteia.
OMIM - 605717
RefSeq - XM_017028310
RefSeq - NM_001283050
RefSeq - NM_001283051
RefSeq - NM_001283052
RefSeq - NM_015259
RefSeq - XM_011529514
RefSeq - XM_011529515
RefSeq Peptide - NP_056074
RefSeq Peptide - NP_001269981
RefSeq Peptide - NP_001269980
RefSeq Peptide - NP_001269979
swissprot - K4DIA0
swissprot - O75144
swissprot - A0N0L8
Ensembl - ENSG00000160223
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ICOSLGENSGALG00000031637Gallus gallus
 IcoslENSMUSG00000000732Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FP565260.3ENSG00000277117100
CD276 / Q5ZPR3 / CD276 moleculeENSG0000010385528
VTCN1 / Q7Z7D3 / V-set domain containing T cell activation inhibitor 1ENSG0000013425817
HHLA2 / Q9UM44 / HERV-H LTR-associating 2ENSG0000011445517


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006952 defense response NAS
 biological_processGO:0006972 hyperosmotic response NAS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0042104 positive regulation of activated T cell proliferation TAS
 biological_processGO:0042110 T cell activation NAS
 biological_processGO:0042113 B cell activation IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Costimulation by the CD28 family


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163600 ICOS / Q9Y6W8 / inducible T cell costimulator  / complex / reaction






 

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