ENSG00000162039


Homo sapiens

Features
Gene ID: ENSG00000162039
  
Biological name :MEIOB
  
Synonyms : MEIOB / meiosis specific with OB domains / Q8N635
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p13.3
Gene start: 1833987
Gene end: 1884294
  
Corresponding Affymetrix probe sets: 237265_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457416
Ensembl peptide - ENSP00000380504
Ensembl peptide - ENSP00000314484
Ensembl peptide - ENSP00000457427
Ensembl peptide - ENSP00000456880
NCBI entrez gene - 254528     See in Manteia.
OMIM - 617670
RefSeq - NM_001163560
RefSeq - NM_152764
RefSeq Peptide - NP_001157032
RefSeq Peptide - NP_689977
swissprot - Q8N635
swissprot - H3BSU6
swissprot - H3BU10
swissprot - H3BU18
Ensembl - ENSG00000162039
  
Related genetic diseases (OMIM): 617706 - ?Spermatogenic failure 22, 617706
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 meiobENSDARG00000062442Danio rerio
 MEIOBENSGALG00000005411Gallus gallus
 MeiobENSMUSG00000024155Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR012340  Nucleic acid-binding, OB-fold
 IPR035203  Cell division control protein 24, OB domain 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000712 resolution of meiotic recombination intermediates ISS
 biological_processGO:0000724 double-strand break repair via homologous recombination ISS
 biological_processGO:0007129 synapsis ISS
 biological_processGO:0007140 male meiotic nuclear division ISS
 biological_processGO:0007141 male meiosis I IEA
 biological_processGO:0007144 female meiosis I ISS
 biological_processGO:0009566 fertilization ISS
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003697 single-stranded DNA binding ISS
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0008310 single-stranded DNA 3"-5" exodeoxyribonuclease activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000837 Elevated gonadotropins 
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 HP:0008734 Decreased testicular size 
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 HP:0011961 Non-obstructive azoospermia "Absence of any measurable level of sperm in his semen, resulting from a defect in the production of spermatozoa in the testes. Can be differentiated from obstructive azoospermia on the basis of testicular biopsy." [HPO:probinson, pmid:20514278]
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 HP:0011962 Obstructive azoospermia "Absence of any measurable level of sperm in his semen, resulting from post-testicular obstruction or retrograde ejaculation. Can be differentiated from obstructive azoospermia on the basis of testicular biopsy." [HPO:probinson, pmid:20514278]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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