ENSG00000162267


Homo sapiens

Features
Gene ID: ENSG00000162267
  
Biological name :ITIH3
  
Synonyms : inter-alpha-trypsin inhibitor heavy chain 3 / ITIH3 / Q06033
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.1
Gene start: 52794768
Gene end: 52809009
  
Corresponding Affymetrix probe sets: 205755_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000413922
Ensembl peptide - ENSP00000479928
Ensembl peptide - ENSP00000415769
NCBI entrez gene - 3699     See in Manteia.
OMIM - 146650
RefSeq - XM_005265105
RefSeq - XM_017006356
RefSeq - NM_002217
RefSeq Peptide - NP_002208
swissprot - Q06033
swissprot - E7ET33
swissprot - A0A087WW43
Ensembl - ENSG00000162267
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itih1ENSDARG00000055053Danio rerio
 itih3aENSDARG00000055036Danio rerio
 ENSGALG00000001697Gallus gallus
 Itih3ENSMUSG00000006522Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITIH1 / P19827 / inter-alpha-trypsin inhibitor heavy chain 1ENSG0000005595755
ITIH4 / Q14624 / inter-alpha-trypsin inhibitor heavy chain family member 4ENSG0000005595541
ITIH2 / P19823 / inter-alpha-trypsin inhibitor heavy chain 2ENSG0000015165540
ITIH6 / Q6UXX5 / inter-alpha-trypsin inhibitor heavy chain family member 6ENSG0000010231333
ITIH5 / inter-alpha-trypsin inhibitor heavy chain family member 5ENSG0000012324327


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR010600  Inter-alpha-trypsin inhibitor heavy chain, C-terminal
 IPR013694  VIT domain
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030212 hyaluronan metabolic process IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0031089 platelet dense granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004866 endopeptidase inhibitor activity TAS
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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