ENSG00000151655


Homo sapiens

Features
Gene ID: ENSG00000151655
  
Biological name :ITIH2
  
Synonyms : inter-alpha-trypsin inhibitor heavy chain 2 / ITIH2 / P19823
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p14
Gene start: 7703269
Gene end: 7749520
  
Corresponding Affymetrix probe sets: 204987_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000351190
Ensembl peptide - ENSP00000368906
Ensembl peptide - ENSP00000388826
NCBI entrez gene - 3698     See in Manteia.
OMIM - 146640
RefSeq - NM_002216
RefSeq Peptide - NP_002207
swissprot - P19823
swissprot - Q5T985
swissprot - Q5T987
Ensembl - ENSG00000151655
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itih2ENSDARG00000045516Danio rerio
 ITIH2ENSGALG00000006833Gallus gallus
 Itih2ENSMUSG00000037254Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ITIH3 / Q06033 / inter-alpha-trypsin inhibitor heavy chain 3ENSG0000016226737
ITIH1 / P19827 / inter-alpha-trypsin inhibitor heavy chain 1ENSG0000005595736
ITIH4 / Q14624 / inter-alpha-trypsin inhibitor heavy chain family member 4ENSG0000005595532
ITIH6 / Q6UXX5 / inter-alpha-trypsin inhibitor heavy chain family member 6ENSG0000010231330
ITIH5 / inter-alpha-trypsin inhibitor heavy chain family member 5ENSG0000012324325


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR010600  Inter-alpha-trypsin inhibitor heavy chain, C-terminal
 IPR013694  VIT domain
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030212 hyaluronan metabolic process IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0004866 endopeptidase inhibitor activity TAS
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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