ENSG00000162946


Homo sapiens

Features
Gene ID: ENSG00000162946
  
Biological name :DISC1
  
Synonyms : DISC1 / disrupted in schizophrenia 1 / Q9NRI5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q42.2
Gene start: 231626815
Gene end: 232041272
  
Corresponding Affymetrix probe sets: 1563744_a_at (Human Genome U133 Plus 2.0 Array)   206090_s_at (Human Genome U133 Plus 2.0 Array)   207759_s_at (Human Genome U133 Plus 2.0 Array)   217330_at (Human Genome U133 Plus 2.0 Array)   233207_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000473386
Ensembl peptide - ENSP00000473261
Ensembl peptide - ENSP00000473417
Ensembl peptide - ENSP00000491762
Ensembl peptide - ENSP00000487190
Ensembl peptide - ENSP00000482174
Ensembl peptide - ENSP00000481791
Ensembl peptide - ENSP00000473586
Ensembl peptide - ENSP00000473425
Ensembl peptide - ENSP00000295051
Ensembl peptide - ENSP00000320784
Ensembl peptide - ENSP00000355592
Ensembl peptide - ENSP00000355593
Ensembl peptide - ENSP00000355596
Ensembl peptide - ENSP00000355597
Ensembl peptide - ENSP00000403888
Ensembl peptide - ENSP00000415147
Ensembl peptide - ENSP00000440909
Ensembl peptide - ENSP00000440953
Ensembl peptide - ENSP00000441193
Ensembl peptide - ENSP00000443996
NCBI entrez gene - 27185     See in Manteia.
OMIM - 605210
RefSeq - NM_001164551
RefSeq - NM_001012957
RefSeq - NM_001012958
RefSeq - NM_001012959
RefSeq - NM_001164537
RefSeq - NM_001164538
RefSeq - NM_001164539
RefSeq - NM_001164540
RefSeq - NM_001164541
RefSeq - NM_001164542
RefSeq - NM_001164544
RefSeq - NM_001164545
RefSeq - NM_001164546
RefSeq - NM_001164547
RefSeq - NM_001164548
RefSeq - NM_001164549
RefSeq - NM_001164553
RefSeq - NM_001164554
RefSeq - NM_001164555
RefSeq - NM_001164556
RefSeq - NM_018662
RefSeq Peptide - NP_001158025
RefSeq Peptide - NP_001158026
RefSeq Peptide - NP_001158012
RefSeq Peptide - NP_001158013
RefSeq Peptide - NP_001158014
RefSeq Peptide - NP_001158016
RefSeq Peptide - NP_001158017
RefSeq Peptide - NP_001158018
RefSeq Peptide - NP_001158019
RefSeq Peptide - NP_001158020
RefSeq Peptide - NP_001158021
RefSeq Peptide - NP_001158023
RefSeq Peptide - NP_001158027
RefSeq Peptide - NP_001158028
RefSeq Peptide - NP_061132
RefSeq Peptide - NP_001012975
RefSeq Peptide - NP_001012976
RefSeq Peptide - NP_001012977
RefSeq Peptide - NP_001158009
RefSeq Peptide - NP_001158010
RefSeq Peptide - NP_001158011
swissprot - A0A075B6Q7
swissprot - C4P0B0
swissprot - C4P0A0
swissprot - C4P093
swissprot - Q5T409
swissprot - Q9NRI5
swissprot - C4P092
swissprot - A0A087WYX6
swissprot - H0Y7U2
swissprot - C4P0B1
Ensembl - ENSG00000162946
  
Related genetic diseases (OMIM): 604906 - {Schizophrenia 9, susceptibility to}, 604906
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 disc1ENSDARG00000021895Danio rerio
 DISC1ENSGALG00000039349Gallus gallus
 Disc1ENSMUSG00000043051Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026081  Disrupted in schizophrenia 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0002052 positive regulation of neuroblast proliferation IGI
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IGI
 biological_processGO:0032091 negative regulation of protein binding ISS
 biological_processGO:1905515 non-motile cilium assembly IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0097546 ciliary base IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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