ENSMUSG00000043051


Mus musculus

Features
Gene ID: ENSMUSG00000043051
  
Biological name :Disc1
  
Synonyms : Disc1 / Disrupted in schizophrenia 1 homolog / Q811T9
  
Possible biological names infered from orthology : disrupted in schizophrenia 1 / Q9NRI5
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E2
Gene start: 125054195
Gene end: 125261858
  
Corresponding Affymetrix probe sets: 10576538 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000112757
Ensembl peptide - ENSMUSP00000112929
Ensembl peptide - ENSMUSP00000074147
Ensembl peptide - ENSMUSP00000075145
Ensembl peptide - ENSMUSP00000095914
Ensembl peptide - ENSMUSP00000111552
Ensembl peptide - ENSMUSP00000112410
Ensembl peptide - ENSMUSP00000112593
NCBI entrez gene - 244667     See in Manteia.
MGI - MGI:2447658
RefSeq - XM_011248388
RefSeq - NM_174853
RefSeq - XM_011248387
RefSeq - NM_174854
RefSeq Peptide - NP_777279
RefSeq Peptide - NP_777278
swissprot - Z4YLG9
swissprot - Q811T9
swissprot - D3YYC9
Ensembl - ENSMUSG00000043051
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 disc1ENSDARG00000021895Danio rerio
 DISC1ENSGALG00000039349Gallus gallus
 DISC1ENSG00000162946Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026081  Disrupted in schizophrenia 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization ISO
 biological_processGO:0001764 neuron migration ISO
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IEA
 biological_processGO:0002052 positive regulation of neuroblast proliferation ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008104 protein localization IDA
 biological_processGO:0010975 regulation of neuron projection development IMP
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0021799 cerebral cortex radially oriented cell migration IMP
 biological_processGO:0021846 cell proliferation in forebrain IMP
 biological_processGO:0021852 pyramidal neuron migration IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IMP
 biological_processGO:0031929 TOR signaling IMP
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0034613 cellular protein localization IDA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0051560 mitochondrial calcium ion homeostasis IMP
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic ISO
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0060998 regulation of dendritic spine development IEA
 biological_processGO:0071539 protein localization to centrosome IEA
 biological_processGO:0090128 regulation of synapse maturation IMP
 biological_processGO:1905515 non-motile cilium assembly ISO
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle IDA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030286 dynein complex IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton ISO
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0090724 central region of growth cone IEA
 cellular_componentGO:0097546 ciliary base ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019894 kinesin binding IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Foxp3tm3Tch/Foxp3+
Genetic Background: C.129X1-Foxp3tm3Tch

Allelic Composition: Disc1Rgsc1393/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1393

Allelic Composition: Disc1Rgsc1390/Disc1Rgsc1390
Genetic Background: B6.Cg-Disc1Rgsc1390

Allelic Composition: Disc1Rgsc1390/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1390

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Foxp3tm3Tch/Foxp3+
Genetic Background: C.129X1-Foxp3tm3Tch

Allelic Composition: Disc1Rgsc1393/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1393

Allelic Composition: Disc1Rgsc1390/Disc1Rgsc1390
Genetic Background: B6.Cg-Disc1Rgsc1390

Allelic Composition: Disc1Rgsc1390/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1390

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Disc1Rgsc1390/Disc1Rgsc1393
Genetic Background: B6.Cg-Disc1Rgsc1390/Disc1Rgsc1393

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0001423 abnormal liquid preference "the desire to drink more or less fluids than average, or to drink unusual fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm3Tch/Foxp3+
Genetic Background: C.129X1-Foxp3tm3Tch

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Disc1Rgsc1390/Disc1Rgsc1393
Genetic Background: B6.Cg-Disc1Rgsc1390/Disc1Rgsc1393

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Disc1Rgsc1393/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1393

Allelic Composition: Disc1Rgsc1390/Disc1Rgsc1390
Genetic Background: B6.Cg-Disc1Rgsc1390

Allelic Composition: Disc1Rgsc1390/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1390

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1+
Genetic Background: (129S2/SvPasCrl x C57BL)F1

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trhtm1Mmt/Trhtm1Mmt
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Disc1tm1Kara/Disc1+
Genetic Background: B6.129S6-Disc1tm1Kara

Allelic Composition: Disc1del/Disc1del
Genetic Background: B6.129S6-Disc1del

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxp3tm3Tch/Foxp3+
Genetic Background: C.129X1-Foxp3tm3Tch

Allelic Composition: Disc1Rgsc1393/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1393

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
Show

Allelic Composition: Foxp3tm3Tch/Foxp3+
Genetic Background: C.129X1-Foxp3tm3Tch

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0002915 abnormal synaptic depression "changes in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
Show

Allelic Composition: Foxp3tm3Tch/Foxp3+
Genetic Background: C.129X1-Foxp3tm3Tch

Allelic Composition: Disc1Rgsc1390/Disc1Rgsc1393
Genetic Background: B6.Cg-Disc1Rgsc1390/Disc1Rgsc1393

Allelic Composition: Disc1Rgsc1390/Disc1Rgsc1390
Genetic Background: B6.Cg-Disc1Rgsc1390

Allelic Composition: Disc1Rgsc1390/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1390

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Foxp3tm3Tch/Foxp3+
Genetic Background: C.129X1-Foxp3tm3Tch

Allelic Composition: Disc1Rgsc1393/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1393

Allelic Composition: Disc1Rgsc1390/Disc1Rgsc1390
Genetic Background: B6.Cg-Disc1Rgsc1390

Allelic Composition: Disc1Rgsc1390/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1390

 MP:0006299 abnormal latent inhibition of conditioning behavior "anomaly in the impairment in a conditioned response seen after repeated unpaired presentations of the conditioned stimulus prior to pairing it with the unconditioned stimulus" [Additction research lab:http://dionysus.psych.wisc.edu/ARL/research-current.html, brs:Beverly Richards-Smith_IMSR Curator, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3tm3Tch/Foxp3+
Genetic Background: C.129X1-Foxp3tm3Tch

Allelic Composition: Disc1Rgsc1390/Disc1Rgsc1390
Genetic Background: B6.Cg-Disc1Rgsc1390

Allelic Composition: Disc1Rgsc1390/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1390

 MP:0006300 abnormal entorhinal cortex morphology "any structural anomaly of the structure in the anterior parahippocampus that lies forward of the parahippocampal cortex and immediately medial to the perirhinal cortex, bounded superiorly by the hippocampus and inferiorly by the collateral sulcus" [brs:Beverly Richards-Smith_IMSR Curator]
Show

Allelic Composition: Foxp3tm3Tch/Foxp3+
Genetic Background: C.129X1-Foxp3tm3Tch

Allelic Composition: Disc1Rgsc1393/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1393

Allelic Composition: Disc1Rgsc1390/Disc1Rgsc1390
Genetic Background: B6.Cg-Disc1Rgsc1390

Allelic Composition: Disc1Rgsc1390/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1390

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxp3tm3Tch/Foxp3+
Genetic Background: C.129X1-Foxp3tm3Tch

Allelic Composition: Disc1Rgsc1390/Disc1Rgsc1390
Genetic Background: B6.Cg-Disc1Rgsc1390

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009745 abnormal behavioral response to xenobiotic "any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1+
Genetic Background: (129S2/SvPasCrl x C57BL)F1

Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
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Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0010070 decreased serotonin concentration "reduction in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0010698 abnormal impulsive behavior control "any anomaly in the ability of an individual to exert restraint over behavior" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sgcatm1Kcam/Sgcatm1Kcam,Sgcetm1Vinni/Sgcetm1Vinni
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0012347 low sweet preference "subjects demonstrate a low predilection for sweet tasting substances over other offered substances" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho/Disc1del
Genetic Background: 129S2/SvPasCrl-Disc1del Disc1tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho

 MP:0020527 small thalamus "decreased size of the thalamus" [MGI:smb]
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Allelic Composition: Foxp3tm3Tch/Foxp3+
Genetic Background: C.129X1-Foxp3tm3Tch

Allelic Composition: Disc1Rgsc1393/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1393

Allelic Composition: Disc1Rgsc1390/Disc1Rgsc1390
Genetic Background: B6.Cg-Disc1Rgsc1390

Allelic Composition: Disc1Rgsc1390/Disc1+
Genetic Background: B6.Cg-Disc1Rgsc1390

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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