ENSG00000163221


Homo sapiens

Features
Gene ID: ENSG00000163221
  
Biological name :S100A12
  
Synonyms : P80511 / S100A12 / S100 calcium binding protein A12
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.3
Gene start: 153373706
Gene end: 153375649
  
Corresponding Affymetrix probe sets: 205863_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357726
NCBI entrez gene - 6283     See in Manteia.
OMIM - 603112
RefSeq - NM_005621
RefSeq Peptide - NP_005612
swissprot - P80511
Ensembl - ENSG00000163221
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P28318ENSGALG00000024272Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P06702 / S100A9 / S100 calcium binding protein A9ENSG0000016322047


Protein motifs (from Interpro)
Interpro ID Name
 IPR001751  S100/Calbindin-D9k, conserved site
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR013787  S100/CaBP-9k-type, calcium binding, subdomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002548 monocyte chemotaxis TAS
 biological_processGO:0006805 xenobiotic metabolic process IDA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0030593 neutrophil chemotaxis TAS
 biological_processGO:0031640 killing of cells of other organism IEA
 biological_processGO:0042742 defense response to bacterium TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043406 positive regulation of MAP kinase activity TAS
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0045576 mast cell activation TAS
 biological_processGO:0050663 cytokine secretion TAS
 biological_processGO:0050729 positive regulation of inflammatory response TAS
 biological_processGO:0050832 defense response to fungus TAS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 molecular_functionGO:0005507 copper ion binding TAS
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050786 RAGE receptor binding TAS


Pathways (from Reactome)
Pathway description
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Neutrophil degranulation
Advanced glycosylation endproduct receptor signaling
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163221 P80511 / S100A12 / S100 calcium binding protein A12  / complex






 

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