ENSG00000163235


Homo sapiens

Features
Gene ID: ENSG00000163235
  
Biological name :TGFA
  
Synonyms : P01135 / TGFA / transforming growth factor alpha
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p13.3
Gene start: 70447280
Gene end: 70554193
  
Corresponding Affymetrix probe sets: 205015_s_at (Human Genome U133 Plus 2.0 Array)   205016_at (Human Genome U133 Plus 2.0 Array)   211258_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000414127
Ensembl peptide - ENSP00000377787
Ensembl peptide - ENSP00000295400
Ensembl peptide - ENSP00000404131
Ensembl peptide - ENSP00000407432
Ensembl peptide - ENSP00000387493
Ensembl peptide - ENSP00000404099
NCBI entrez gene - 7039     See in Manteia.
OMIM - 190170
RefSeq - NM_003236
RefSeq - NM_001099691
RefSeq - NM_001308158
RefSeq - NM_001308159
RefSeq Peptide - NP_001093161
RefSeq Peptide - NP_003227
RefSeq Peptide - NP_001295088
RefSeq Peptide - NP_001295087
swissprot - P01135
swissprot - E7EPT6
swissprot - F8VNR3
swissprot - F8WA74
swissprot - H0Y6S5
Ensembl - ENSG00000163235
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgfaENSDARG00000053939Danio rerio
 TGFAENSGALG00000024024Gallus gallus
 TgfaENSMUSG00000029999Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BTC / P35070 / betacellulinENSG0000017480824


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site
 IPR015497  Epidermal growth factor receptor ligand


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity IDA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IDA
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0048523 negative regulation of cellular process IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060749 mammary gland alveolus development IEA
 biological_processGO:0072574 hepatocyte proliferation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IDA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Cargo concentration in the ER
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000327 Hypoplasia of the maxilla "Underdevelopment of the `Maxilla` (FMA:9711)." [HPO:probinson]
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 HP:0000347 Mandibular hypoplasia "Underdevelopment of the mandible." [HPO:curators]
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 HP:0000677 Oligodontia "The condition of missing over 6 teeth (Missing up to 6 teeth is referred to a hypodontia)." [HPO:curators]
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 HP:0000691 Microdontia 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100528 CNIH1 / O95406 / cornichon family AMPA receptor auxiliary protein 1  / reaction / complex






 

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