ENSMUSG00000029999


Mus musculus

Features
Gene ID: ENSMUSG00000029999
  
Biological name :Tgfa
  
Synonyms : P48030 / Tgfa / transforming growth factor alpha
  
Possible biological names infered from orthology : P01135
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: D1
Gene start: 86195223
Gene end: 86275719
  
Corresponding Affymetrix probe sets: 10539692 (MoGene1.0st)   1421942_s_at (Mouse Genome 430 2.0 Array)   1421943_at (Mouse Genome 430 2.0 Array)   1450421_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141395
Ensembl peptide - ENSMUSP00000032066
NCBI entrez gene - 21802     See in Manteia.
MGI - MGI:98724
RefSeq - NM_031199
RefSeq Peptide - NP_112476
swissprot - A0A0A6YW49
swissprot - P48030
swissprot - Q545E4
Ensembl - ENSMUSG00000029999
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tgfaENSDARG00000053939Danio rerio
 TGFAENSGALG00000024024Gallus gallus
 TGFAENSG00000163235Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Btc / Q05928 / Probetacellulin Betacellulin / P35070* / betacellulin*ENSMUSG0000008236125


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site
 IPR015497  Epidermal growth factor receptor ligand


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IBA
 biological_processGO:0001525 angiogenesis IDA
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045741 positive regulation of epidermal growth factor-activated receptor activity ISS
 biological_processGO:0045840 positive regulation of mitotic nuclear division ISS
 biological_processGO:0048523 negative regulation of cellular process IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation ISS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060749 mammary gland alveolus development IGI
 biological_processGO:0072574 hepatocyte proliferation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IDA
 molecular_functionGO:0008083 growth factor activity ISS


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Cargo concentration in the ER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfawa1-5J/Tgfawa1-5J
Genetic Background: BXD32/Ty-Tgfawa1-5J

 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000396 increased curvature of hairs "distinct C- or S- shaped curvature of the hairs" [J:4606]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0000402 abnormal zigzag hairs "anomalies of truncal hairs that contain one air cell in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfawa1-5J/Tgfawa1-5J
Genetic Background: BXD32/Ty-Tgfawa1-5J

 MP:0000410 waved hair "hair or fur having undulations or a sinusoidal shape" [J:47620]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tgfawa1-5J/Tgfawa1-5J
Genetic Background: BXD32/Ty-Tgfawa1-5J

Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Egftm1Dle/Egftm1Dle,Eregtm1Dwt/Eregtm1Dwt,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001278 kinked vibrissae "sharp bends in the vibrissae" [J:56641]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001279 wavy vibrissae "whiskers having undulations or a sinusoidal shape" [J:65044]
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Allelic Composition: Tgfawa1-5J/Tgfawa1-5J
Genetic Background: BXD32/Ty-Tgfawa1-5J

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tgfawa1-5J/Tgfawa1-5J
Genetic Background: BXD32/Ty-Tgfawa1-5J

Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Egftm1Dle/Egftm1Dle,Eregtm1Dwt/Eregtm1Dwt,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001313 increased incidence of corneal inflammation "greater than average and persistent occurrence of corneal irritation" [J:4606]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001316 corneal scarring "appearance of fibrous tissue on the cornea after healing in response to injury " [J:30249]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001340 abnormal eyelid morphology "malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001510 abnormal coat appearance "coat that looks different from the usual state " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: EgfrWa5/Egfr+,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0002074 abnormal hair texture "irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfawa1-5J/Tgfawa1-5J
Genetic Background: BXD32/Ty-Tgfawa1-5J

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcirg1tm1Ypl/Tcirg1tm1Ypl
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Tgfawa1-5J/Tgfawa1-5J
Genetic Background: BXD32/Ty-Tgfawa1-5J

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfawa1-5J/Tgfawa1-5J
Genetic Background: BXD32/Ty-Tgfawa1-5J

 MP:0002580 duodenal lesions "any pathological change in the structure of the wall of the duodenum" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002581 abnormal ileum morphology "malformation of the portion of the small intestine that extends from the jejunum to the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70183]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003095 abnormal corneal stroma development "anomalous differentiaton of the lamellated connective tissue layer of the cornea" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:81616]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003671 abnormal eyelid opening 
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0003812 abnormal hair medulla "anomalies of hair medullary cell formation and arrangement of the innermost core of the hair shaft " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004285 absent Descemet membrane "absence of the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea" [J:4605, J:73681, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: EgfrWa5/Egfr+,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * BALB/cAnN * C3H/HeN * C57BL/6J

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006194 keratoconjunctivitis "inflammation of the conjunctiva and cornea" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008841 ruptured lens capsule "a break or tear in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008852 retinal neovascularization "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0009272 decreased guard hair length "reduction in the length of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities"]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0009651 abnormal eyelid development "aberrant formation of the skin folds covering the front of the eyeball" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009742 increased corneal stroma thickness "increased width of the lamellated connective tissue layer of the cornea" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfawa1/Tgfawa1
Genetic Background: Not Specified

 MP:0010709 absent anterior chamber "absence of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MESH:A09.371.060.067]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0013389 Meibomian gland hypoplasia "underdevelopment or reduced size of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate, usually due to a reduced number of cells" [MGI:Anna]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0013396 eyelid hyperplasia "overdevelopment or increased size of the skin folds covering the front of the eyeball, usually due to an increased cell number" [MGI:Anna]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0013716 hypolactation "partial failure, or reduced ability to produce or secrete milk from the mammary gland" [MGI:Anna]
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Allelic Composition: Aregtm1Dle/Aregtm1Dle,Egftm1Dle/Egftm1Dle,Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030175 orbicularis oculi muscle hypoplasia "underdevelopment or reduced size of the orbicularis oculi muscle, usually due to a reduced number of cells" [MGI:anna]
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Allelic Composition: Tgfatm1Unc/Tgfatm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015759 1 / Cnih1 / O35372 / O95406* / cornichon family AMPA receptor auxiliary protein 1*  / complex / reaction






 

1 s.

 
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