ENSG00000163794


Homo sapiens

Features
Gene ID: ENSG00000163794
  
Biological name :UCN
  
Synonyms : P55089 / UCN / urocortin
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p23.3
Gene start: 27307400
Gene end: 27308445
  
Corresponding Affymetrix probe sets: 206072_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000296099
NCBI entrez gene - 7349     See in Manteia.
OMIM - 600945
RefSeq - NM_003353
RefSeq Peptide - NP_003344
swissprot - P55089
Ensembl - ENSG00000163794
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uts1ENSDARG00000014927Danio rerio
 UcnENSMUSG00000038676Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000187  Corticotropin-releasing factor
 IPR003620  Urocortin/corticotropin-releasing factor
 IPR018446  Corticotropin-releasing factor conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001964 startle response IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0008306 associative learning IEA
 biological_processGO:0009060 aerobic respiration IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010996 response to auditory stimulus IEA
 biological_processGO:0030157 pancreatic juice secretion IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0031064 negative regulation of histone deacetylation IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032099 negative regulation of appetite IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034199 activation of protein kinase A activity IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035483 gastric emptying IEA
 biological_processGO:0042756 drinking behavior IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043117 positive regulation of vascular permeability IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045792 negative regulation of cell size IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046888 negative regulation of hormone secretion IEA
 biological_processGO:0048265 response to pain IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051461 positive regulation of corticotropin secretion IEA
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060452 positive regulation of cardiac muscle contraction IEA
 biological_processGO:0060455 negative regulation of gastric acid secretion IEA
 biological_processGO:0060547 negative regulation of necrotic cell death IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0090280 positive regulation of calcium ion import IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:2000252 negative regulation of feeding behavior IEA
 biological_processGO:2000987 positive regulation of behavioral fear response IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043196 varicosity IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046811 histone deacetylase inhibitor activity IEA
 molecular_functionGO:0051430 corticotropin-releasing hormone receptor 1 binding IEA
 molecular_functionGO:0051431 corticotropin-releasing hormone receptor 2 binding IEA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000120088 CRHR1 / P34998 / corticotropin releasing hormone receptor 1  / reaction / complex
 ENSG00000106113 CRHR2 / Q13324 / corticotropin releasing hormone receptor 2  / complex / reaction






 

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