ENSG00000120088


Homo sapiens

Features
Gene ID: ENSG00000120088
  
Biological name :CRHR1
  
Synonyms : corticotropin releasing hormone receptor 1 / CRHR1 / P34998
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.31
Gene start: 45784280
Gene end: 45835828
  
Corresponding Affymetrix probe sets: 208593_x_at (Human Genome U133 Plus 2.0 Array)   211897_s_at (Human Genome U133 Plus 2.0 Array)   214619_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463852
Ensembl peptide - ENSP00000484545
Ensembl peptide - ENSP00000340522
Ensembl peptide - ENSP00000326060
Ensembl peptide - ENSP00000293493
Ensembl peptide - ENSP00000239167
Ensembl peptide - ENSP00000462016
Ensembl peptide - ENSP00000462553
Ensembl peptide - ENSP00000463177
Ensembl peptide - ENSP00000344068
Ensembl peptide - ENSP00000381333
Ensembl peptide - ENSP00000439934
NCBI entrez gene - 1394     See in Manteia.
NCBI entrez gene - 104909134     See in Manteia.
OMIM - 122561
RefSeq - NM_001303016
RefSeq - NM_004382
RefSeq - NM_001145146
RefSeq - NM_001145147
RefSeq - NM_001145148
RefSeq - NM_001303020
RefSeq Peptide - NP_001138619
RefSeq Peptide - NP_001138618
RefSeq Peptide - NP_004373
RefSeq Peptide - NP_001289949
RefSeq Peptide - NP_001289945
RefSeq Peptide - NP_001138620
swissprot - P34998
swissprot - A0A0A0MQZ1
swissprot - B3TIK8
swissprot - H0YFR5
swissprot - J3KSM0
swissprot - J3QKP8
swissprot - J3QQR1
swissprot - J9JIC6
swissprot - K9J956
Ensembl - ENSG00000120088
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crhr1ENSDARG00000003989Danio rerio
 CRHR1ENSGALG00000000371Gallus gallus
 Crhr1ENSMUSG00000018634Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CRHR2 / Q13324 / corticotropin releasing hormone receptor 2ENSG0000010611365
LINC02210-CRHR1 / LINC02210-CRHR1 readthroughENSG0000026371554
CALCR / P30988 / calcitonin receptorENSG0000000494827
CALCRL / Q16602 / calcitonin receptor like receptorENSG0000006498926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003051  GPCR, family 2, corticotropin releasing factor receptor
 IPR003052  GPCR, family 2, corticotropin releasing factor receptor, type 1
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007565 female pregnancy NAS
 biological_processGO:0007567 parturition TAS
 biological_processGO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway IMP
 biological_processGO:0051458 corticotropin secretion ISS
 biological_processGO:0071376 cellular response to corticotropin-releasing hormone stimulus IDA
 biological_processGO:1901386 negative regulation of voltage-gated calcium channel activity IDA
 biological_processGO:2000852 regulation of corticosterone secretion ISS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015056 corticotrophin-releasing factor receptor activity IDA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000147571 CRH / P06850 / corticotropin releasing hormone  / reaction / complex
 ENSG00000163794 UCN / P55089 / urocortin  / reaction / complex






 

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