ENSG00000004948


Homo sapiens

Features
Gene ID: ENSG00000004948
  
Biological name :CALCR
  
Synonyms : calcitonin receptor / CALCR / P30988
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q21.3
Gene start: 93424487
Gene end: 93574730
  
Corresponding Affymetrix probe sets: 207886_s_at (Human Genome U133 Plus 2.0 Array)   207887_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000353385
Ensembl peptide - ENSP00000377959
Ensembl peptide - ENSP00000413179
Ensembl peptide - ENSP00000399552
Ensembl peptide - ENSP00000391369
Ensembl peptide - ENSP00000389295
Ensembl peptide - ENSP00000352561
NCBI entrez gene - 799     See in Manteia.
OMIM - 114131
RefSeq - NM_001742
RefSeq - NM_001164737
RefSeq - NM_001164738
RefSeq Peptide - NP_001158209
RefSeq Peptide - NP_001158210
RefSeq Peptide - NP_001733
swissprot - P30988
swissprot - A0A0C4DG16
swissprot - A0A0A0MSQ7
swissprot - A0A0A0MRG0
swissprot - D8MIV0
Ensembl - ENSG00000004948
  
Related genetic diseases (OMIM): 166710 - {Osteoporosis, postmenopausal, susceptibility}, 166710
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CalcrENSMUSG00000023964Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CALCRL / Q16602 / calcitonin receptor like receptorENSG0000006498951
CRHR2 / Q13324 / corticotropin releasing hormone receptor 2ENSG0000010611325
CRHR1 / P34998 / corticotropin releasing hormone receptor 1ENSG0000012008824
LINC02210-CRHR1 / LINC02210-CRHR1 readthroughENSG0000026371515


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001688  GPCR, family 2, calcitonin receptor
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003287  GPCR, family 2, calcitonin receptor family
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0010739 positive regulation of protein kinase A signaling IGI
 biological_processGO:0010942 positive regulation of cell death IGI
 biological_processGO:0015031 protein transport IDA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030316 osteoclast differentiation IEA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process IGI
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IGI
 biological_processGO:0043488 regulation of mRNA stability IEA
 biological_processGO:0051384 response to glucocorticoid IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IGI
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IGI
 biological_processGO:0072659 protein localization to plasma membrane IDA
 biological_processGO:0097647 amylin receptor signaling pathway IGI
 biological_processGO:1905665 positive regulation of calcium ion import across plasma membrane IGI
 cellular_componentGO:0001669 acrosomal vesicle IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:1903440 amylin receptor complex IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004948 calcitonin receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008565 protein transporter activity IDA
 molecular_functionGO:0032841 calcitonin binding IPI
 molecular_functionGO:0097643 amylin receptor activity IGI


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Calcitonin-like ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000122679 RAMP3 / O60896 / receptor activity modifying protein 3  / complex
 ENSG00000131477 RAMP2 / O60895 / receptor activity modifying protein 2  / complex
 ENSG00000121351 IAPP / P10997 / islet amyloid polypeptide  / reaction / complex
 ENSG00000132329 RAMP1 / O60894 / receptor activity modifying protein 1  / complex
 ENSG00000110680 CALCA / P01258 / P06881 / calcitonin related polypeptide alpha  / complex / reaction






 

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