ENSG00000110680


Homo sapiens

Features
Gene ID: ENSG00000110680
  
Biological name :CALCA
  
Synonyms : CALCA / calcitonin related polypeptide alpha / P01258 / P06881
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.2
Gene start: 14966668
Gene end: 14972354
  
Corresponding Affymetrix probe sets: 210727_at (Human Genome U133 Plus 2.0 Array)   210728_s_at (Human Genome U133 Plus 2.0 Array)   217495_x_at (Human Genome U133 Plus 2.0 Array)   217561_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420618
Ensembl peptide - ENSP00000331746
Ensembl peptide - ENSP00000354286
Ensembl peptide - ENSP00000379657
Ensembl peptide - ENSP00000417833
NCBI entrez gene - 796     See in Manteia.
OMIM - 114130
RefSeq - XM_017018284
RefSeq - NM_001033952
RefSeq - NM_001033953
RefSeq - NM_001741
RefSeq - XM_017018283
RefSeq Peptide - NP_001732
RefSeq Peptide - NP_001029124
RefSeq Peptide - NP_001029125
swissprot - P01258
swissprot - P06881
Ensembl - ENSG00000110680
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CALCBENSGALG00000006054Gallus gallus
 CalcaENSMUSG00000030669Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CALCB / P10092 / calcitonin related polypeptide betaENSG0000017586852


Protein motifs (from Interpro)
Interpro ID Name
 IPR001693  Calcitonin peptide-like
 IPR015476  Calcitonin gene-related peptide
 IPR018360  Calcitonin, conserved site
 IPR021116  Calcitonin/adrenomedullin
 IPR021117  Calcitonin-like
 IPR021118  Calcitonin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001935 endothelial cell proliferation IDA
 biological_processGO:0001944 vasculature development IDA
 biological_processGO:0001984 artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure IEA
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0002031 G-protein coupled receptor internalization IDA
 biological_processGO:0002548 monocyte chemotaxis IDA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007190 activation of adenylate cyclase activity IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007566 embryo implantation IDA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0008016 regulation of heart contraction IEA
 biological_processGO:0008217 regulation of blood pressure NAS
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010523 negative regulation of calcium ion transport into cytosol IDA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process IGI
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0031645 negative regulation of neurological system process IEA
 biological_processGO:0032147 activation of protein kinase activity IDA
 biological_processGO:0032730 positive regulation of interleukin-1 alpha production IDA
 biological_processGO:0032757 positive regulation of interleukin-8 production IDA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0043542 endothelial cell migration IDA
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045651 positive regulation of macrophage differentiation IDA
 biological_processGO:0045671 negative regulation of osteoclast differentiation IDA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045778 positive regulation of ossification IEA
 biological_processGO:0045779 negative regulation of bone resorption IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045986 negative regulation of smooth muscle contraction IEA
 biological_processGO:0048265 response to pain IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IDA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0097647 amylin receptor signaling pathway IGI
 biological_processGO:0097755 positive regulation of blood vessel diameter IDA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990408 calcitonin gene-related peptide receptor signaling pathway IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043195 terminal bouton IEA
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031716 calcitonin receptor binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IDA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Calcitonin-like ligand receptors
Amyloid fiber formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000064989 CALCRL / Q16602 / calcitonin receptor like receptor  / reaction / complex
 ENSG00000110680 CALCA / P01258 / P06881 / calcitonin related polypeptide alpha  / -
 ENSG00000132329 RAMP1 / O60894 / receptor activity modifying protein 1  / complex / reaction
 ENSG00000004948 CALCR / P30988 / calcitonin receptor  / reaction / complex






 

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