ENSMUSG00000030669


Mus musculus

Features
Gene ID: ENSMUSG00000030669
  
Biological name :Calca
  
Synonyms : Calca / Calcitonin-related peptide 1 / P70160 / Q99JA0
  
Possible biological names infered from orthology : calcitonin related polypeptide alpha / P01258 / P06881
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F1
Gene start: 114631478
Gene end: 114636357
  
Corresponding Affymetrix probe sets: 10567095 (MoGene1.0st)   1427355_at (Mouse Genome 430 2.0 Array)   1452004_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146280
Ensembl peptide - ENSMUSP00000145756
Ensembl peptide - ENSMUSP00000146328
Ensembl peptide - ENSMUSP00000032906
Ensembl peptide - ENSMUSP00000032907
Ensembl peptide - ENSMUSP00000145548
NCBI entrez gene - 12310     See in Manteia.
MGI - MGI:2151253
RefSeq - XM_017321960
RefSeq - NM_001033954
RefSeq - NM_001289444
RefSeq - NM_001305616
RefSeq - NM_007587
RefSeq - XM_011241660
RefSeq - XM_017321958
RefSeq - XM_017321959
RefSeq Peptide - NP_001292545
RefSeq Peptide - NP_031613
RefSeq Peptide - NP_001029126
RefSeq Peptide - NP_001276373
swissprot - Q99JA0
swissprot - A0A0U1RNZ0
swissprot - A0A0U1RNG0
swissprot - P70160
Ensembl - ENSMUSG00000030669
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CALCBENSGALG00000006054Gallus gallus
 CALCAENSG00000110680Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Calcb / calcitonin related polypeptide beta / P10092*ENSMUSG0000003066642


Protein motifs (from Interpro)
Interpro ID Name
 IPR001693  Calcitonin peptide-like
 IPR015476  Calcitonin gene-related peptide
 IPR018360  Calcitonin, conserved site
 IPR021116  Calcitonin/adrenomedullin
 IPR021117  Calcitonin-like
 IPR021118  Calcitonin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001976 neurological system process involved in regulation of systemic arterial blood pressure ISA
 biological_processGO:0001984 artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure IMP
 biological_processGO:0002027 regulation of heart rate IMP
 biological_processGO:0002548 monocyte chemotaxis IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IGI
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IGI
 biological_processGO:0007190 activation of adenylate cyclase activity ISA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007218 neuropeptide signaling pathway IDA
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007631 feeding behavior IDA
 biological_processGO:0008016 regulation of heart contraction IEA
 biological_processGO:0009408 response to heat IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030279 negative regulation of ossification IMP
 biological_processGO:0031645 negative regulation of neurological system process IMP
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0045776 negative regulation of blood pressure ISA
 biological_processGO:0045778 positive regulation of ossification IMP
 biological_processGO:0045779 negative regulation of bone resorption IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045986 negative regulation of smooth muscle contraction IDA
 biological_processGO:0048240 sperm capacitation ISA
 biological_processGO:0048265 response to pain IMP
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IMP
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043195 terminal bouton IDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0031716 calcitonin receptor binding IDA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Calcitonin-like ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

 MP:0001562 abnormal circulating calcium level "anomalous concentration in the blood of this bivalent element" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0001771 abnormal circulating magnesium level "anomalous blood concentration of this bioelement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0001980 abnormal chemically-elicited antinociception "change in the analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irak4m1Btlr/Irak4m1Btlr,Ticam1Lps2/Ticam1Lps2
Genetic Background: involves: C57BL/6J

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

 MP:0003929 decreased heart rate variability "reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission]
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Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004183 abnormal sympathetic nervous system physiology "anomaly in the function of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004738 abnormal brainstem auditory evoked potential "anomaly in the electrical activity generated in response to short tone bursts; may be used to evaluate sensorineural hearing function" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004746 abnormal cochlear IHC afferent innervation "any changes in the morphology or number of afferent terminals and/or their synapses in the cochlear IHC region" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmp2tm1Cjt/Bmp2tm1Cjt,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004878 increased systemic vascular resistance "increase in the normal force opposing blood flow in the peripheral blood vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Fgf10tm1Ska/Fgf10Tg(Myl3-lacZ)24Buck
Genetic Background: involves: C57BL/6 * CBA

 MP:0006263 decreased diastolic blood pressure "abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Fgf10tm1Ska/Fgf10Tg(Myl3-lacZ)24Buck
Genetic Background: involves: C57BL/6 * CBA

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0008715 lung small cell carcinoma "an anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm" [MESH:C04.557.465.625.650.240.390]
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Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Plautm1Mlg/Plautm1Mlg
Genetic Background: involves: 129 * C57BL/6

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcoln3Va-J/?
Genetic Background: involves: C3HeB/FeJLe * C57BL/6J

 MP:0009752 enhanced behavioral response to nicotine "increased sensitivity to nicotine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0009776 decreased behavioral withdrawal response "decrease in the intensity or duration of behaviors displayed after discontinuation of an addictive substance" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1Rob/Nodaltm2Rob
Genetic Background: involves: 129S/SvEv * ICR

 MP:0010316 increased thyroid tumor incidence "greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

 MP:0010809 abnormal Clara cell morphology "any structural anomaly of the rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium, believed to be secretory in function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: A/A,Tyrc-ch/Tyrc-ch
Genetic Background: Not Specified

 MP:0010918 abnormal pulmonary neuroendocrine bodies "any structural anomaly of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: A/A,Tyrc-ch/Tyrc-ch
Genetic Background: Not Specified

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N

Allelic Composition: Calcatm1.1(cre/ERT2)Ptch/Calca+,Trp53tm1Brn/Trp53tm1Brn,Rb1tm2Brn/Rb1tm2Brn,Ptentm1Hwu/Ptentm1Hwu
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S4/SvJae * BALB/c * FVB/N

 MP:0011478 abnormal urine catecholamine level "any anomaly in the urinary amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines are act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [MGI:csmith]
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Allelic Composition: Ly6atm1Grau/Ly6atm1Grau
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic Background: B6.129(Cg)-Rapgef3tm1.1Chen

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023964 Calcr / Q60755 / Mus musculus calcitonin receptor (Calcr), transcript variant 3, mRNA. / P30988* / calcitonin receptor*  / reaction / complex
 ENSMUSG00000034353 Ramp1 / Q9WTJ5 / receptor (calcitonin) activity modifying protein 1 / O60894* / receptor activity modifying protein 1*  / complex / reaction
 ENSMUSG00000059588 Calcrl / Q9R1W5 / Calcitonin-related peptide type 1 receptor / Q16602* / calcitonin receptor like receptor*  / reaction / complex






 

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