ENSMUSG00000034353


Mus musculus

Features
Gene ID: ENSMUSG00000034353
  
Biological name :Ramp1
  
Synonyms : Q9WTJ5 / Ramp1 / receptor (calcitonin) activity modifying protein 1
  
Possible biological names infered from orthology : O60894 / receptor activity modifying protein 1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 91179822
Gene end: 91225196
  
Corresponding Affymetrix probe sets: 10348537 (MoGene1.0st)   1417481_at (Mouse Genome 430 2.0 Array)   1431413_at (Mouse Genome 430 2.0 Array)   1447474_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139720
Ensembl peptide - ENSMUSP00000095253
Ensembl peptide - ENSMUSP00000128679
NCBI entrez gene - 51801     See in Manteia.
MGI - MGI:1858418
RefSeq - XM_017321671
RefSeq - NM_001168392
RefSeq - NM_016894
RefSeq - NM_178401
RefSeq Peptide - NP_848488
RefSeq Peptide - NP_001161864
RefSeq Peptide - NP_058590
swissprot - A0A087WPC6
swissprot - E9Q915
swissprot - Q3TNJ3
swissprot - Q9WTJ5
Ensembl - ENSMUSG00000034353
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:91818ENSDARG00000056704Danio rerio
 RAMP1ENSGALG00000003821Gallus gallus
 RAMP1ENSG00000132329Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ramp3 / Q9WUP1 / Receptor activity-modifying protein 3 / O60896*ENSMUSG0000004104630
Ramp2 / Q9WUP0 / Receptor activity-modifying protein 2 / O60895*ENSMUSG0000000124027


Protein motifs (from Interpro)
Interpro ID Name
 IPR006985  Receptor activity modifying protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IPI
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0060050 positive regulation of protein glycosylation ISO
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0097647 amylin receptor signaling pathway IEA
 biological_processGO:1990408 calcitonin gene-related peptide receptor signaling pathway ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:1903440 amylin receptor complex ISO
 cellular_componentGO:1990406 CGRP receptor complex ISO
 molecular_functionGO:0001635 calcitonin gene-related peptide receptor activity IEA
 molecular_functionGO:0008565 protein transporter activity ISO
 molecular_functionGO:0015026 coreceptor activity IEA
 molecular_functionGO:0097643 amylin receptor activity ISO
 molecular_functionGO:1990407 calcitonin gene-related peptide binding ISO


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Calcitonin-like ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005634 decreased circulating sodium level "less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Nkx6-2tm1Ercs/Nkx6-2tm1Ercs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030669 Calca / Q99JA0 / P70160 / Calcitonin-related peptide 1 / P01258* / P06881* / calcitonin related polypeptide alpha*  / complex / reaction
 ENSMUSG00000041681 Iapp / P12968 / Islet amyloid polypeptide / P10997*  / complex / reaction
 ENSMUSG00000030666 Calcb / calcitonin related polypeptide beta / P10092*  / complex / reaction
 ENSMUSG00000023964 Calcr / Q60755 / Mus musculus calcitonin receptor (Calcr), transcript variant 3, mRNA. / P30988* / calcitonin receptor*  / complex
 ENSMUSG00000059588 Calcrl / Q9R1W5 / Calcitonin-related peptide type 1 receptor / Q16602* / calcitonin receptor like receptor*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr