ENSMUSG00000023964


Mus musculus

Features
Gene ID: ENSMUSG00000023964
  
Biological name :Calcr
  
Synonyms : Calcr / Mus musculus calcitonin receptor (Calcr), transcript variant 3, mRNA. / Q60755
  
Possible biological names infered from orthology : calcitonin receptor / P30988
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A1
Gene start: 3685680
Gene end: 3764714
  
Corresponding Affymetrix probe sets: 10542929 (MoGene1.0st)   1418688_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132124
Ensembl peptide - ENSMUSP00000111285
Ensembl peptide - ENSMUSP00000130083
Ensembl peptide - ENSMUSP00000075070
Ensembl peptide - ENSMUSP00000130243
NCBI entrez gene - 12311     See in Manteia.
MGI - MGI:101950
RefSeq - XM_006504973
RefSeq - NM_001042725
RefSeq - NM_001355192
RefSeq - NM_007588
RefSeq - XM_006504972
RefSeq Peptide - NP_031614
RefSeq Peptide - NP_001036190
RefSeq Peptide - NP_001342121
swissprot - Q60755
Ensembl - ENSMUSG00000023964
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CALCRENSG00000004948Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Calcrl / Q9R1W5 / Calcitonin-related peptide type 1 receptor / Q16602* / calcitonin receptor like receptor*ENSMUSG0000005958847
Crhr2 / Q60748 / Corticotropin-releasing factor receptor 2 / Q13324* / corticotropin releasing hormone receptor 2*ENSMUSG0000000347625
Crhr1 / P35347 / Corticotropin-releasing factor receptor 1 / P34998* / LINC02210-CRHR1* / LINC02210-CRHR1 readthrough* / corticotropin releasing hormone receptor 1*ENSMUSG0000001863424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001688  GPCR, family 2, calcitonin receptor
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003287  GPCR, family 2, calcitonin receptor family
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISO
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0010739 positive regulation of protein kinase A signaling ISO
 biological_processGO:0010942 positive regulation of cell death ISO
 biological_processGO:0015031 protein transport ISO
 biological_processGO:0030279 negative regulation of ossification IMP
 biological_processGO:0030316 osteoclast differentiation IDA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0043488 regulation of mRNA stability IDA
 biological_processGO:0045762 positive regulation of adenylate cyclase activity ISO
 biological_processGO:0051384 response to glucocorticoid ISO
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0072659 protein localization to plasma membrane ISO
 biological_processGO:0097647 amylin receptor signaling pathway ISO
 biological_processGO:1905665 positive regulation of calcium ion import across plasma membrane ISO
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:1903440 amylin receptor complex ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004948 calcitonin receptor activity ISO
 molecular_functionGO:0008565 protein transporter activity ISO
 molecular_functionGO:0097643 amylin receptor activity ISO


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Calcitonin-like ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: EdaTa/Eda+,Edaraddcr/Edaradd+
Genetic Background: involves: JU/Fa

 MP:0001562 abnormal circulating calcium level "anomalous concentration in the blood of this bivalent element" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: EdaTa/Eda+,Edaraddcr/Edaradd+
Genetic Background: involves: JU/Fa

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Celsr2tm1Dgen/Celsr2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: EdaTa/Eda+,Edaraddcr/Edaradd+
Genetic Background: involves: JU/Fa

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: EdaTa/Eda+,Edaraddcr/Edaradd+
Genetic Background: involves: JU/Fa

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009345 abnormal cancellous bone thickness "anomaly in the width of bone that has a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa/Eda+,Edaraddcr/Edaradd+
Genetic Background: involves: JU/Fa

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa/Eda+,Edaraddcr/Edaradd+
Genetic Background: involves: JU/Fa

 MP:0010872 increased trabecular bone mass "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa/Eda+,Edaraddcr/Edaradd+
Genetic Background: involves: JU/Fa

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: EdaTa/Eda+,Edaraddcr/Edaradd+
Genetic Background: involves: JU/Fa

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Calcrtm1Dgal/Calcr+,Iapptm1Sgm/Iapp+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030669 Calca / Q99JA0 / P70160 / Calcitonin-related peptide 1 / P01258* / P06881* / calcitonin related polypeptide alpha*  / reaction / complex
 ENSMUSG00000034353 Ramp1 / Q9WTJ5 / receptor (calcitonin) activity modifying protein 1 / O60894* / receptor activity modifying protein 1*  / complex
 ENSMUSG00000041681 Iapp / P12968 / Islet amyloid polypeptide / P10997*  / complex / reaction
 ENSMUSG00000041046 Ramp3 / Q9WUP1 / Receptor activity-modifying protein 3 / O60896*  / complex
 ENSMUSG00000001240 Ramp2 / Q9WUP0 / Receptor activity-modifying protein 2 / O60895*  / complex






 

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