ENSMUSG00000018634


Mus musculus

Features
Gene ID: ENSMUSG00000018634
  
Biological name :Crhr1
  
Synonyms : Corticotropin-releasing factor receptor 1 / Crhr1 / P35347
  
Possible biological names infered from orthology : corticotropin releasing hormone receptor 1 / LINC02210-CRHR1 / LINC02210-CRHR1 readthrough / P34998
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 104132855
Gene end: 104175523
  
Corresponding Affymetrix probe sets: 10381753 (MoGene1.0st)   1418810_at (Mouse Genome 430 2.0 Array)   1427782_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091455
NCBI entrez gene - 12921     See in Manteia.
MGI - MGI:88498
RefSeq - NM_007762
RefSeq - XM_017314247
RefSeq - NM_001313928
RefSeq - NM_001313929
RefSeq - XM_017314246
RefSeq Peptide - NP_031788
RefSeq Peptide - NP_001300857
RefSeq Peptide - NP_001300858
swissprot - P35347
swissprot - Q3ZAT0
Ensembl - ENSMUSG00000018634
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crhr1ENSDARG00000003989Danio rerio
 CRHR1ENSGALG00000000371Gallus gallus
 CRHR1ENSG00000120088Homo sapiens
 LINC02210-CRHR1ENSG00000263715Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Crhr2 / Q60748 / Corticotropin-releasing factor receptor 2 / Q13324* / corticotropin releasing hormone receptor 2*ENSMUSG0000000347668
Calcr / Q60755 / Mus musculus calcitonin receptor (Calcr), transcript variant 3, mRNA. / P30988* / calcitonin receptor*ENSMUSG0000002396430
Calcrl / Q9R1W5 / Calcitonin-related peptide type 1 receptor / Q16602* / calcitonin receptor like receptor*ENSMUSG0000005958829


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003051  GPCR, family 2, corticotropin releasing factor receptor
 IPR003052  GPCR, family 2, corticotropin releasing factor receptor, type 1
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IEA
 biological_processGO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway ISO
 biological_processGO:0021854 hypothalamus development IEA
 biological_processGO:0030325 adrenal gland development IMP
 biological_processGO:0030855 epithelial cell differentiation IEA
 biological_processGO:0032811 negative regulation of epinephrine secretion IEA
 biological_processGO:0035641 locomotory exploration behavior IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0042596 fear response IMP
 biological_processGO:0043306 positive regulation of mast cell degranulation IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0048149 behavioral response to ethanol IMP
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0048266 behavioral response to pain IEA
 biological_processGO:0051458 corticotropin secretion IMP
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0051867 general adaptation syndrome, behavioral process IMP
 biological_processGO:0060291 long-term synaptic potentiation IEA
 biological_processGO:0071376 cellular response to corticotropin-releasing hormone stimulus ISO
 biological_processGO:1901215 negative regulation of neuron death IEA
 biological_processGO:1901386 negative regulation of voltage-gated calcium channel activity ISO
 biological_processGO:2000252 negative regulation of feeding behavior IEA
 biological_processGO:2000852 regulation of corticosterone secretion IMP
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane ISO
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0045177 apical part of cell IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0015056 corticotrophin-releasing factor receptor activity ISO
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0043404 corticotropin-releasing hormone receptor activity IEA
 molecular_functionGO:0051424 corticotropin-releasing hormone binding IEA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000640 adrenal gland hypoplasia "underdeveloped endocrine glands located above the kidney and responsible for hormone and epinephrine secretion, resulting from reduced numbers of cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Crhr1tm1Klee/Crhr1+,Tg(MECP2)1Hzo/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEv * C57BL/6 * FVB/N

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Crhr1tm1Wrst/Crhr1tm1Wrst
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001748 increased circulating adrenocorticotropin level "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Tg(Camk2a-cre)159Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001987 alcohol preference 
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Allelic Composition: Crhr1tm1Wrst/Crhr1tm1Wrst
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Crhr1tm1Wrst/Crhr1tm1Wrst
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crhr1tm2.3Jde/Crhr1tm2.3Jde
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Unc5crcmTg(Tert)5Hwl/Unc5crcmTg(Tert)5Hwl
Genetic Background: involves: FVB/N

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Akr1a1tm1Maka/Akr1a1+
Genetic Background: B6.Cg-Akr1a1tm1Maka

Allelic Composition: Crhr1tm2.3Jde/Crhr1tm2.3Jde
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Crhr1tm1Wrst/Crhr1tm1Wrst
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0003963 abnormal corticosterone level "anomalous blood or tissue concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Cdkn1ctm2.1Kei/Cdkn1c+,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Cdkn1ctm2.1Kei Cdkn1atm1Led Tg(Mx1-cre)1Cgn

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Crhr1tm2.3Jde/Crhr1tm2.3Jde
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6NTac

 MP:0008289 abnormal adrenal medulla morphology "any structural anomaly of the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine" [MESH:A06.407.071.265, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Crhr1tm1Wrst/Crhr1tm1Wrst
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0008294 abnormal zona fasciculata morphology "any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Crhr1tm1Klee/Crhr1tm1Klee,Crhr2tm1Klee/Crhr2tm1Klee
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009776 decreased behavioral withdrawal response "decrease in the intensity or duration of behaviors displayed after discontinuation of an addictive substance" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Crhr1tm1Wrst/Crhr1tm1Wrst
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0010149 abnormal synaptic dopamine release "aberrant secretion across synapses of the catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crhr1tm2Wrst/Crhr1tm2Wrst,Neurod6tm1(cre)Kan/Neurod6+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J

 MP:0010909 pulmonary alveolar hemorrhage "bleeding into the small sac-like dilations of the distal airspace of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038676 Ucn / P81615 / urocortin / P55089*  / reaction / complex
 ENSMUSG00000049796 Crh / Q8CIT0 / Corticoliberin / P06850* / corticotropin releasing hormone*  / reaction / complex






 

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