ENSMUSG00000059588


Mus musculus

Features
Gene ID: ENSMUSG00000059588
  
Biological name :Calcrl
  
Synonyms : Calcitonin-related peptide type 1 receptor / Calcrl / Q9R1W5
  
Possible biological names infered from orthology : calcitonin receptor like receptor / Q16602
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: D
Gene start: 84330626
Gene end: 84425411
  
Corresponding Affymetrix probe sets: 10484371 (MoGene1.0st)   1418489_a_at (Mouse Genome 430 2.0 Array)   1425814_a_at (Mouse Genome 430 2.0 Array)   1459536_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097527
Ensembl peptide - ENSMUSP00000073875
NCBI entrez gene - 54598     See in Manteia.
MGI - MGI:1926944
RefSeq - NM_018782
RefSeq - XM_006499918
RefSeq Peptide - NP_061252
swissprot - A2AR99
swissprot - Q9R1W5
Ensembl - ENSMUSG00000059588
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 calcrlaENSDARG00000011473Danio rerio
 calcrlbENSDARG00000011571Danio rerio
 CALCRLENSGALG00000002632Gallus gallus
 CALCRLENSG00000064989Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Calcr / Q60755 / Mus musculus calcitonin receptor (Calcr), transcript variant 3, mRNA. / P30988* / calcitonin receptor*ENSMUSG0000002396454
Crhr2 / Q60748 / Corticotropin-releasing factor receptor 2 / Q13324* / corticotropin releasing hormone receptor 2*ENSMUSG0000000347627
Crhr1 / P35347 / Corticotropin-releasing factor receptor 1 / P34998* / LINC02210-CRHR1* / LINC02210-CRHR1 readthrough* / corticotropin releasing hormone receptor 1*ENSMUSG0000001863426


Protein motifs (from Interpro)
Interpro ID Name
 IPR000832  GPCR, family 2, secretin-like
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003287  GPCR, family 2, calcitonin receptor family
 IPR003289  GPCR, family 2, calcitonin gene-related peptide, type 1 receptor
 IPR017981  GPCR, family 2-like
 IPR017983  GPCR, family 2, secretin-like, conserved site
 IPR036445  GPCR family 2, extracellular hormone receptor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0006816 calcium ion transport ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0015031 protein transport ISO
 biological_processGO:0031623 receptor internalization ISO
 biological_processGO:0045986 negative regulation of smooth muscle contraction IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IMP
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 biological_processGO:0071329 cellular response to sucrose stimulus ISO
 biological_processGO:1990408 calcitonin gene-related peptide receptor signaling pathway ISO
 biological_processGO:1990410 adrenomedullin receptor signaling pathway ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005768 endosome ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:1903143 adrenomedullin receptor complex ISO
 cellular_componentGO:1990406 CGRP receptor complex ISO
 molecular_functionGO:0001605 adrenomedullin receptor activity ISO
 molecular_functionGO:0001635 calcitonin gene-related peptide receptor activity ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004948 calcitonin receptor activity IEA
 molecular_functionGO:0008565 protein transporter activity ISO
 molecular_functionGO:1990409 adrenomedullin binding ISO


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Calcitonin-like ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Calcrltm1Kmca/Calcrltm2Kmca,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002450 abnormal lymph organ development "anomaly in the process of morphological maturation of the organs of the lymph system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003288 intestinal edema "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003390 lymphedema "abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008876 decreased uterine NK cell number "reduced number of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Calcrltm1Kmca/Calcrltm2Kmca,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J

 MP:0012727 abnormal uterine spiral artery remodeling "any anomaly of the physiological conversion of the uterine spiral arteries into highly dilated vessels by the action of invading trophoblast; in pregnancy, trophoblast invasion and uterine spiral artery remodeling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow; this process involves loss of smooth muscle and elastic lamina from the vessel wall, and significant dilation at the mouth of the vessel; impaired spiral artery remodeling has been implicated in preeclampsia, fetal growth restriction, and preterm labor" [MGI:anna]
Show

Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030790 Adm / P97297 / ADM Adrenomedullin Proadrenomedullin N-20 terminal peptide / P35318* / adrenomedullin*  / complex / reaction
 ENSMUSG00000054136 Adm2 / Q7TNK8 / ADM2 Adrenomedullin-2 Intermedin-short / Q7Z4H4* / adrenomedullin 2*  / reaction / complex
 ENSMUSG00000030669 Calca / Q99JA0 / P70160 / Calcitonin-related peptide 1 / P01258* / P06881* / calcitonin related polypeptide alpha*  / complex / reaction
 ENSMUSG00000001240 Ramp2 / Q9WUP0 / Receptor activity-modifying protein 2 / O60895*  / complex
 ENSMUSG00000030666 Calcb / calcitonin related polypeptide beta / P10092*  / complex / reaction
 ENSMUSG00000041046 Ramp3 / Q9WUP1 / Receptor activity-modifying protein 3 / O60896*  / complex
 ENSMUSG00000034353 Ramp1 / Q9WTJ5 / receptor (calcitonin) activity modifying protein 1 / O60894* / receptor activity modifying protein 1*  / complex






 

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