ENSMUSG00000030790


Mus musculus

Features
Gene ID: ENSMUSG00000030790
  
Biological name :Adm
  
Synonyms : Adm / ADM Adrenomedullin Proadrenomedullin N-20 terminal peptide / P97297
  
Possible biological names infered from orthology : adrenomedullin / P35318
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E3
Gene start: 110627661
Gene end: 110629820
  
Corresponding Affymetrix probe sets: 10556297 (MoGene1.0st)   1416077_at (Mouse Genome 430 2.0 Array)   1447839_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033054
NCBI entrez gene - 11535     See in Manteia.
MGI - MGI:108058
RefSeq - NM_009627
RefSeq Peptide - NP_033757
swissprot - P97297
Ensembl - ENSMUSG00000030790
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 admaENSDARG00000015263Danio rerio
 ADMENSGALG00000046593Gallus gallus
 ADMENSG00000148926Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001710  Adrenomedullin
 IPR021116  Calcitonin/adrenomedullin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0002026 regulation of the force of heart contraction IEA
 biological_processGO:0002031 G-protein coupled receptor internalization IEA
 biological_processGO:0003073 regulation of systemic arterial blood pressure IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008209 androgen metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019933 cAMP-mediated signaling IEA
 biological_processGO:0030816 obsolete positive regulation of cAMP metabolic process IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031102 neuron projection regeneration IEA
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0035809 regulation of urine volume IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0042594 response to starvation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043116 negative regulation of vascular permeability IMP
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045906 negative regulation of vasoconstriction IEA
 biological_processGO:0046879 hormone secretion IEA
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0055074 calcium ion homeostasis IEA
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IMP
 biological_processGO:0060712 spongiotrophoblast layer development IMP
 biological_processGO:0097084 vascular smooth muscle cell development IMP
 biological_processGO:0097647 amylin receptor signaling pathway IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1990410 adrenomedullin receptor signaling pathway IEA
 biological_processGO:2001214 positive regulation of vasculogenesis IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0031700 adrenomedullin receptor binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Calcitonin-like ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Mapttm1(Mecp2)Jae/Mapt+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Admtm1Unc/Adm+,Tg(Alb1-Ren)2Unc/?
Genetic Background: 129S6/SvEvTac-Admtm1Unc Tg(Alb1-Ren)2Unc

 MP:0001711 abnormal placenta 
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Allelic Composition: Mapttm1(Mecp2)Jae/Mapt+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Calcrltm1Kmca/Calcrltm2Kmca,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J

 MP:0001863 vascular inflammation "local accumulation of fluid, plasma proteins, and leukocytes in a blood vessel" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53Bbl/Trp53+
Genetic Background: C57BL/6JSfdAnu-Trp53Bbl/Anu

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002450 abnormal lymph organ development "anomaly in the process of morphological maturation of the organs of the lymph system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Calcrltm1Kmca/Calcrltm2Kmca,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Admtm1Unc/Adm+,Tg(Alb1-Ren)2Unc/?
Genetic Background: 129S6/SvEvTac-Admtm1Unc Tg(Alb1-Ren)2Unc

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003044 impaired basement membrane formation "defect in the organization and/or placement of the extracellular supportive tissue closely adjacent to the basal surface of the epithelium of muscle cells, fat cells and Schwann cells, which is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003390 lymphedema "abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Calcrltm1Kmca/Calcrltm2Kmca,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6J

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp53Bbl/Trp53+
Genetic Background: C57BL/6JSfdAnu-Trp53Bbl/Anu

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Admtm1Unc/Adm+,Tg(Alb1-Ren)2Unc/?
Genetic Background: 129S6/SvEvTac-Admtm1Unc Tg(Alb1-Ren)2Unc

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Trp53Bbl/Trp53+
Genetic Background: C57BL/6JSfdAnu-Trp53Bbl/Anu

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Admtm1Unc/Adm+,Tg(Alb1-Ren)2Unc/?
Genetic Background: 129S6/SvEvTac-Admtm1Unc Tg(Alb1-Ren)2Unc

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Admtm1Unc/Adm+,Tg(Alb1-Ren)2Unc/?
Genetic Background: 129S6/SvEvTac-Admtm1Unc Tg(Alb1-Ren)2Unc

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005558 decreased creatinine clearance "less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008876 decreased uterine NK cell number "reduced number of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0009394 increased uterine NK cell number "increased number of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; uNK cells contribute to uterine decidualization and are recruited to implantation sites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm1Hwu/Pten+,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0009658 increased placenta apoptosis "increase in the number of cells of the placenta undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009820 abnormal liver vasculature morphology "any structural anomaly of the blood vessel network of the bile-secreting exocrine gland" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tbx4tm1.2Pa/Tbx4tm1.2Pa,Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

Allelic Composition: Admtm1Unc/Admtm1Unc
Genetic Background: 129S6/SvEvTac-Admtm1Unc

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Trp53Bbl/Trp53+
Genetic Background: C57BL/6JSfdAnu-Trp53Bbl/Anu

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
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Allelic Composition: Admtm1Unc/Adm+,Tg(Alb1-Ren)2Unc/?
Genetic Background: 129S6/SvEvTac-Admtm1Unc Tg(Alb1-Ren)2Unc

 MP:0011514 skin hemorrhage "bleeding into the skin" [MGI:anna]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011525 abnormal placenta intervillous maternal lacunae morphology "any structural anomaly of the spaces of the placenta occupied by maternal blood, into which the fetal labyrinth villi project" [MGI:csmith]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0011526 abnormal placenta fetal blood space morphology "any structural anomaly of the spaces of the placenta occupied by fetal blood, primarily within the fetal labyrinth villi" [MGI:csmith]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

 MP:0011942 decreased fluid intake "reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012302 umbilical artery stenosis "abnormal constriction or narrowing of one or both umbilical arteries that carry deoxygenated, nutrient-depleted blood from the fetus to the placenta" [MGI:anna]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012303 umbilical vein stenosis "abnormal constriction or narrowing of the unpaired umbilical vein that carries oxygenated, nutrient-rich blood from the placenta to the fetus" [MGI:anna]
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Allelic Composition: Admtm1Hku/Admtm1Hku
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012727 abnormal uterine spiral artery remodeling "any anomaly of the physiological conversion of the uterine spiral arteries into highly dilated vessels by the action of invading trophoblast; in pregnancy, trophoblast invasion and uterine spiral artery remodeling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow; this process involves loss of smooth muscle and elastic lamina from the vessel wall, and significant dilation at the mouth of the vessel; impaired spiral artery remodeling has been implicated in preeclampsia, fetal growth restriction, and preterm labor" [MGI:anna]
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Allelic Composition: Egfrwa2/Egfrwa2,Ptpn11tm1Paw/Ptpn11+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * B6EiC3Sn a/A-Egfrwa2 Wnt3avt * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041046 Ramp3 / Q9WUP1 / Receptor activity-modifying protein 3 / O60896*  / complex / reaction
 ENSMUSG00000059588 Calcrl / Q9R1W5 / Calcitonin-related peptide type 1 receptor / Q16602* / calcitonin receptor like receptor*  / reaction / complex
 ENSMUSG00000001240 Ramp2 / Q9WUP0 / Receptor activity-modifying protein 2 / O60895*  / reaction / complex






 

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